ELECTROMAGNETICALLY INDUCED DISTORTION OF A FIBRIN MATRIX WITH EMBEDDED MICROPARTICLES.
ELECTROMAGNETICALLY INDUCED DISTORTION OF A FIBRIN MATRIX WITH EMBEDDED MICROPARTICLES.
复制标题
嵌入微粒的纤维蛋白基质的电磁诱导变形。
DOI：
10.1142/s0219519418500161
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发表时间：
2018
影响因子：
0.8
通讯作者：
Averett,RodneyD
中科院分区：
文献类型：
--
作者：
Scogin,Tyler;Yesudasan,Sumith;Walker,MitchellLR;Averett,RodneyD
血凝块是人体需要防止出血时产生的。在病理状态，如糖尿病和镰状细胞病，血凝块也可形成不希望由于高凝血浆条件。随着纤维蛋白治疗方法的不断发展，需要更多的力学建模来了解含有内含物的纤维蛋白结构的特性。在这项研究中，嵌入磁性微颗粒（MMPs）的纤维蛋白基质受到磁场的影响，以确定在纤维蛋白凝块内产生塑性变形所需的力的大小。利用有限元（FE）分析，我们估计了位于距离线圈中心约3cm的样品空间的电磁铁的磁力。将这种电磁力与重力耦合作用于具有MMPs的纤维蛋白机械系统上，以计算应力和位移。使用适当的线圈参数，确定需要在纤维蛋白表面施加730A/m的磁场才能获得36nN的电磁力（以产生塑性变形）。
Blood clots occur in the human body when they are required to prevent bleeding. In pathological states such as diabetes and sickle cell disease, blood clots can also form undesirably due to hypercoagulable plasma conditions. With the continued effort in developing fibrin therapies for potential life-saving solutions, more mechanical modeling is needed to understand the properties of fibrin structures with inclusions. In this study, a fibrin matrix embedded with magnetic micro particles (MMPs) was subjected to a magnetic field to determine the magnitude of the required force to create plastic deformation within the fibrin clot. Using finite element (FE) analysis, we estimated the magnetic force from an electromagnet at a sample space located approximately 3cm away from the coil center. This electromagnetic force coupled with gravity was applied on a fibrin mechanical system with MMPs to calculate the stresses and displacements. Using appropriate coil parameters, it was determined that application of a magnetic field of 730A/m on the fibrin surface was necessary to achieve an electromagnetic force of 36nN (to engender plastic deformation).
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影响因子：
3.8
作者：
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通讯作者：
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