Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.
Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats.
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DOI：
10.1371/journal.pone.0110124
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Fan HY
中科院分区：
文献类型：
--
作者：
Yu C;Qi D;Lian W;Li QZ;Li HJ;Fan HY
丹参素是一种二羟基苯乳酸类化合物，是唇形科植物丹参中含量最丰富的活性酚酸类化合物之一。采用多种方法观察丹参素对大鼠血小板聚集和血栓形成的影响。结果发现，丹参素能显著降低2种实验性血栓形成模型的血栓重量;对正常大鼠和血瘀模型大鼠的二磷酸腺苷（ADP）和花生四烯酸（AA）诱导的血小板聚集均有剂量依赖性抑制作用;丹参素还能显著降低全血粘度、血浆粘度和红细胞压积水平。丹参素还能显著抑制静脉血栓形成诱导的静脉壁环氧合酶-2（考克斯-2）而非环氧合酶-1（考克斯-1）的表达，下调血栓素B2（TXB 2），上调6-酮-前列腺素F1α（6-keto-PGF 1 α），使TXB 2/6-keto-PGF 1 α比值正常化。此外，丹参素不诱导胃损伤，甚至在高达60 mg/kg的剂量下对阿司匹林诱导的溃疡形成具有保护作用。这些结果表明，丹参素的抗血栓形成和抗血小板聚集作用归因于其高度选择性地抑制考克斯-2和使血栓素A2（TXA 2）/前列环素（PGI 2）平衡正常化的能力。这些结果表明丹参素在抗血栓和抗血小板治疗方面具有广阔的应用前景。
Danshensu, a type of dihydroxyphenyl lactic acid, is one of the most abundant active phenolic acids in the dried root of Salvia miltiorrhizae (Lamiaceae)—widely used traditional Chinese medicine. The effects of danshensu on platelet aggregation and thrombus formation in rats were examined using various methods. It was found that danshensu significantly reduced thrombus weight in 2 experimental thrombosis models; dose-dependent inhibition of adenosine diphosphate (ADP) and arachidonic acid (AA)-induced platelet aggregation occurred in normal and blood stasis-induced rats; Danshensu also significantly mitigated blood viscosity, plasma viscosity and hematocrit levels. Moreover, danshensu significantly inhibited venous thrombosis-induced expression of cyclooxygenases-2 (COX-2) rather than cyclooxygenases-1(COX-1) in the venous walls, down regulated thromboxane B2 (TXB2) and up regulated 6-keto prostaglandin F1α (6-keto-PGF1α), normalizing the TXB2/6-keto-PGF1α ratio. In addition, danshensu did not induce gastric lesions and even had protective effects on aspirin-induced ulcer formation at doses as high as 60 mg/kg. These findings suggest that the antithrombotic and antiplatelet aggregation effects of danshensu are attributed to its highly selective inhibition of COX-2 and ability to normalize the thromboxane A2(TXA2)/prostacyclin(PGI2) balance. These findings suggest that danshensu have great prospects in antithrombotic and antiplatelet therapy.
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影响因子：
29.4
作者：
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通讯作者：
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作者：
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作者：
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