Large-scale mitochondrial DNA analysis in Southeast Asia reveals evolutionary effects of cultural isolation in the multi-ethnic population of Myanmar.
Large-scale mitochondrial DNA analysis in Southeast Asia reveals evolutionary effects of cultural isolation in the multi-ethnic population of Myanmar.
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DOI：
10.1186/1471-2148-14-17
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发表时间：
2014-01-28
影响因子：
3.4
通讯作者：
Kloss-Brandstätter A
中科院分区：
文献类型：
--
作者：
Summerer M;Horst J;Erhart G;Weißensteiner H;Schönherr S;Pacher D;Forer L;Horst D;Manhart A;Horst B;Sanguansermsri T;Kloss-Brandstätter A
缅甸是东南亚大陆最大的国家，人口5500万，分为100多个民族。缅甸由不断变化的王国和王朝统治，位于印度和中国之间的贸易路线上，受到多种文化的影响。自脱离英国占领独立以来，执政的不丹与少数民族之间的紧张关系加剧。我们的目标是寻找缅甸地理、历史和社会文化特征的遗传足迹，并通过描述和确定新的线粒体DNA单倍群的年代，为人类殖民化的图景做出贡献。因此，我们根据最高质量标准对327名无关供体的mtDNA控制区和44名选定个体的完整线粒体基因组进行了测序。对整个mtDNA基因组的系统发育分析发现了8个新的单倍型群和3个未分类的基础M谱系。缅甸的多民族人口和复杂的历史反映在其mtDNA的异质性。缅甸控制区序列的群体遗传分析结合邻国的人口数据显示，缅甸单倍型群分布显示出典型的东南亚模式，但也有东北亚和印度的影响。非常多样化的Bethesia人的人口结构与显示出遗传隔离迹象的Karen人不同。移民分析表明，从缅甸到邻国的移民总体上是积极的，有相当大的遗传交流。新描述的单倍群的年龄估计指出存在的进化窗口，气候和文化的变化引起了线粒体单倍群多样化在亚洲。
Myanmar is the largest country in mainland Southeast Asia with a population of 55 million people subdivided into more than 100 ethnic groups. Ruled by changing kingdoms and dynasties and lying on the trade route between India and China, Myanmar was influenced by numerous cultures. Since its independence from British occupation, tensions between the ruling Bamar and ethnic minorities increased. Our aim was to search for genetic footprints of Myanmar’s geographic, historic and sociocultural characteristics and to contribute to the picture of human colonization by describing and dating of new mitochondrial DNA (mtDNA) haplogroups. Therefore, we sequenced the mtDNA control region of 327 unrelated donors and the complete mitochondrial genome of 44 selected individuals according to highest quality standards. Phylogenetic analyses of the entire mtDNA genomes uncovered eight new haplogroups and three unclassified basal M-lineages. The multi-ethnic population and the complex history of Myanmar were reflected in its mtDNA heterogeneity. Population genetic analyses of Burmese control region sequences combined with population data from neighboring countries revealed that the Myanmar haplogroup distribution showed a typical Southeast Asian pattern, but also Northeast Asian and Indian influences. The population structure of the extraordinarily diverse Bamar differed from that of the Karen people who displayed signs of genetic isolation. Migration analyses indicated a considerable genetic exchange with an overall positive migration balance from Myanmar to neighboring countries. Age estimates of the newly described haplogroups point to the existence of evolutionary windows where climatic and cultural changes gave rise to mitochondrial haplogroup diversification in Asia.
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影响因子：
3.1
作者：
Irwin, Jodi A.;Saunier, Jessica L.;Parsons, Thomas J.
通讯作者：
Parsons, Thomas J.
影响因子：
3.7
作者：
Derenko M;Malyarchuk B;Denisova G;Perkova M;Rogalla U;Grzybowski T;Khusnutdinova E;Dambueva I;Zakharov I
通讯作者：
Zakharov I
影响因子：
10.7
作者：
Hill, Catherine;Soares, Pedro;Richards, Martin
通讯作者：
Richards, Martin
影响因子：
2.1
作者：
Irwin, Jodi A.;Ikramov, Abror;Parsons, Thomas J.
通讯作者：
Parsons, Thomas J.
影响因子：
5.8
作者：
Beerli, P
通讯作者：
Beerli, P