Complete mitochondrial DNA analysis of eastern Eurasian haplogroups rarely found in populations of northern Asia and eastern Europe.
Complete mitochondrial DNA analysis of eastern Eurasian haplogroups rarely found in populations of northern Asia and eastern Europe.
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DOI：
10.1371/journal.pone.0032179
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Zakharov I
中科院分区：
文献类型：
--
作者：
Derenko M;Malyarchuk B;Denisova G;Perkova M;Rogalla U;Grzybowski T;Khusnutdinova E;Dambueva I;Zakharov I
为了揭示北亚线粒体DNA （mtDNA）单倍群中所有最基本的变异，我们分析了来自西伯利亚南部的98名阿尔泰哈萨克人和来自内蒙古的149名巴尔古特人的mtDNA控制区和编码区序列变异。这两个种群都表现出东欧亚血统的流行，巴尔古特人占91.9%，阿尔泰哈萨克人占60.2%。揭示了阿尔泰哈萨克人与北亚和中亚人群的强烈亲缘关系，这既反映了中亚居民的影响，也反映了与阿尔泰地区土著人群的重要遗传相互作用。统计分析数据表明，所有说蒙古语的人群（蒙古人、布里亚特人、卡姆尼干人、卡尔梅克人以及这里研究的巴尔古特人）和说突厥语的索约特人的定位都很接近，因此表明他们来自一个共同的母系祖先基因库。为了实现对北亚母系基因库DNA谱系的全面覆盖，我们从北亚和东亚以及欧洲对照区大量收集（超过5000个个体）的mtDNA序列中确定了55个样品的单倍群R11b、B4、B5、F2、M9、M10、M11、M13、N9a和R9c1的mtDNA序列进行了完整的测序。将新更新的mtDNA树应用于先前报道的北亚和东亚mtDNA数据集，解决了mtDNA类型分类不佳的状况，并使我们能够使用不同的校准率获得感兴趣节点的合并年龄估计。我们的研究结果证实了我们之前的结论，即北亚母亲基因库主要由东亚祖先的LGM后成分组成，尽管一些遗传谱系可能具有LGM/LGM前起源。
With the aim of uncovering all of the most basal variation in the northern Asian mitochondrial DNA (mtDNA) haplogroups, we have analyzed mtDNA control region and coding region sequence variation in 98 Altaian Kazakhs from southern Siberia and 149 Barghuts from Inner Mongolia, China. Both populations exhibit the prevalence of eastern Eurasian lineages accounting for 91.9% in Barghuts and 60.2% in Altaian Kazakhs. The strong affinity of Altaian Kazakhs and populations of northern and central Asia has been revealed, reflecting both influences of central Asian inhabitants and essential genetic interaction with the Altai region indigenous populations. Statistical analyses data demonstrate a close positioning of all Mongolic-speaking populations (Mongolians, Buryats, Khamnigans, Kalmyks as well as Barghuts studied here) and Turkic-speaking Sojots, thus suggesting their origin from a common maternal ancestral gene pool. In order to achieve a thorough coverage of DNA lineages revealed in the northern Asian matrilineal gene pool, we have completely sequenced the mtDNA of 55 samples representing haplogroups R11b, B4, B5, F2, M9, M10, M11, M13, N9a and R9c1, which were pinpointed from a massive collection (over 5000 individuals) of northern and eastern Asian, as well as European control region mtDNA sequences. Applying the newly updated mtDNA tree to the previously reported northern Asian and eastern Asian mtDNA data sets has resolved the status of the poorly classified mtDNA types and allowed us to obtain the coalescence age estimates of the nodes of interest using different calibrated rates. Our findings confirm our previous conclusion that northern Asian maternal gene pool consists of predominantly post-LGM components of eastern Asian ancestry, though some genetic lineages may have a pre-LGM/LGM origin.
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影响因子：
2.8
作者：
Dolukhanov, P;Shukurov, A;Zaitseva, G
通讯作者：
Zaitseva, G
影响因子：
5.3
作者：
Derenko, M;Malyarchuk, B;Zakharov, I
通讯作者：
Zakharov, I
影响因子：
56.9
作者：
Gilbert, M. Thomas P.;Kivisild, Toomas;Willerslev, Eske
通讯作者：
Willerslev, Eske
影响因子：
9.8
作者：
Derenko, Miroslava;Malyarchuk, Boris;Zakharov, Ilia
通讯作者：
Zakharov, Ilia
影响因子：
3.7
作者：
Achilli, Alessandro;Perego, Ugo A.;Bravi, Claudio M.;Coble, Michael D.;Kong, Qing-Peng;Woodward, Scott R.;Salas, Antonio;Torroni, Antonio;Bandelt, Hans-Juergen
通讯作者：
Bandelt, Hans-Juergen