Anabolic Bone Stimulus Requires a Pre-Exercise Meal and 45-Minute Walking Impulse of Suprathreshold Speed-Enhanced Momentum to Prevent or Mitigate Postmenopausal Osteoporosis within Circadian Constraints.
Anabolic Bone Stimulus Requires a Pre-Exercise Meal and 45-Minute Walking Impulse of Suprathreshold Speed-Enhanced Momentum to Prevent or Mitigate Postmenopausal Osteoporosis within Circadian Constraints.
复制标题
DOI：
10.3390/nu13113727
复制
发表时间：
2021-10-22
期刊：
影响因子：
5.9
通讯作者：
Borer KT
中科院分区：
文献类型：
--
作者：
Zheng Q;Kernozek T;Daoud-Gray A;Borer KT
骨质疏松症目前困扰着美国800万绝经后妇女，增加了骨折和发病率的风险，并降低了整体生活质量。我们试图定义能够预防绝经后骨质疏松症的适度运动方案。我们之前的发现指出，较高的步行速度和运动前进餐对于抑制骨吸收和增加骨形成标志物是必要的。由于这两项研究都服从不同的生物力学、营养和昼夜节律的解释，我们试图确定更高的速度、动量、速度增强负荷、脉冲持续时间和进餐时间对成骨反应的相对重要性。我们假设：(1)餐后1小时20分钟的锻炼足以抑制骨吸收，与40分钟的冲动一样多，两次20分钟的锻炼间隔7小时将使合成代谢效果加倍；(2)吃完饭后进行的清晨锻炼与中午锻炼对合成代谢的效果相同；(3)08：00小时40分钟。上坡运动和40分钟下坡运动一样具有成骨作用。健康的绝经后妇女，每组8人，被分配到无运动条件(SED)或进行40或20分钟的运动，间隔7h，进行上坡(40上行和20上行)或下坡(40上行和20下行)，以产生生物力学变量的差异。40min组在进食1h后08：00h开始运动，20min组在7h后，即午餐后2h开始运动。测定骨形成标志物CICP、骨钙素(OC)、骨特异性碱性磷酸酶(BALP)和骨吸收标志物CTX(I型胶原c端肽)。计算CICP/CTX、OC/CTX、BALP/CTX的成骨比例。只有40min的下坡运动增加了阈值以上的速度动量，增加了三种成骨比率，证明了40min运动冲动的必要性，而20min运动冲动的不足。在40min的上坡运动中，合成代谢结果的失败归因于甲状旁腺素浓度的持续升高，因为它在早晨的高水平增强了CTX的昼夜节律。我们的结论是，在久坐不动的女性中，可以通过45分钟的晨练来预防或缓解绝经后骨质疏松症，方法是在平地上行走时，在用餐后不久进行45分钟的超阈值速度增强的动量训练，或者通过40分钟的下坡运动，而不是40分钟的上坡运动，以避免昼夜PTH过度分泌。产生合成代谢作用的主要刺激因素是运动，但运动前进餐的前提条件是营养促进。
Osteoporosis currently afflicts 8 million postmenopausal women in the US, increasing the risk of bone fractures and morbidity, and reducing overall quality of life. We sought to define moderate exercise protocols that can prevent postmenopausal osteoporosis. Our previous findings singled out higher walking speed and pre-exercise meals as necessary for suppression of bone resorption and increasing of markers of bone formation. Since both studies were amenable to alternate biomechanical, nutritional, and circadian interpretations, we sought to determine the relative importance of higher speed, momentum, speed-enhanced load, duration of impulse, and meal timing on osteogenic response. We hypothesized that: (1) 20 min of exercise one hour after eating is sufficient to suppress bone resorption as much as a 40-min impulse and that two 20 min exercise bouts separated by 7 h would double the anabolic effect; (2) early morning exercise performed after eating will be as effective as mid-day exercise for anabolic outcome; and (3) the 08:00 h 40-min. exercise uphill would be as osteogenic as the 40-min exercise downhill. Healthy postmenopausal women, 8 each, were assigned to a no-exercise condition (SED) or to 40- or 20-min exercise bouts, spaced 7 h apart, for walking uphill (40 Up and 20 Up) or downhill (40 Down and 20 Down) to produce differences in biomechanical variables. Exercise was initiated at 08:00 h one hour after eating in 40-min groups, and also 7 h later, two hours after the midday meal, in 20-min groups. Measurements were made of CICP (c-terminal peptide of type I collagen), osteocalcin (OC), and bone-specific alkaline phosphatase (BALP), markers of bone formation, and of the bone resorptive marker CTX (c-terminal telopeptide of type 1 collagen). The osteogenic ratios CICP/CTX, OC/CTX, and BALP/CTX were calculated. Only the 40-min downhill exercise of suprathreshold speed-enhanced momentum, increased the three osteogenic ratios, demonstrating the necessity of a 40-min, and inadequacy of a 20-min, exercise impulse. The failure of anabolic outcome in 40-min uphill exercise was attributed to a sustained elevation of PTH concentration, as its high morning elevation enhances the CTX circadian rhythm. We conclude that postmenopausal osteoporosis can be prevented or mitigated in sedentary women by 45 min of morning exercise of suprathreshold speed-enhanced increased momentum performed shortly after a meal while walking on level ground, or by 40-min downhill, but not 40-min uphill, exercise to avoid circadian PTH oversecretion. The principal stimulus for the anabolic effect is exercise, but the prerequisite for a pre-exercise meal demonstrates the requirement for nutrient facilitation.
登录
查看更多内容
影响因子：
4.1
作者：
Henriksen, DB;Alexandersen, P;Holst, JJ
通讯作者：
Holst, JJ
影响因子：
168.9
作者：
Heinonen, A;Kannus, P;Vuori, I
通讯作者：
Vuori, I
影响因子：
5.8
作者：
BRANDENBERGER, G;FOLLENIUS, M
通讯作者：
FOLLENIUS, M
影响因子：
4.1
作者：
Bjarnason, NH;Henriksen, EEG;Christiansen, C
通讯作者：
Christiansen, C
影响因子：
6.2
作者：
Henriksen, DB;Alexandersen, P;Christiansen, C
通讯作者：
Christiansen, C