Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?
Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?
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DOI：
10.1016/j.jinf.2012.10.002
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Yuen KY
中科院分区：
文献类型：
--
作者：
Chan JF;Li KS;To KK;Cheng VC;Chen H;Yuen KY
Fuchier等人。报告了一种新型冠状病毒的分离和基因组序列测定，该病毒暂定名为“人类BetacoronaVirus 2c EMC/2012(HCoV-EMC)”，该病毒来自2012年6月出现肺炎和肾功能衰竭的沙特患者。基因组测序显示，该病毒属于贝塔冠状病毒属C组物种，与此前在香港小竹蝙蝠和日本管蝙蝠中发现的蝙蝠冠状病毒HKU4和HKU5有亲缘关系。2012年9月报告了另一名来自卡塔尔的患者，具有类似的临床表现和RT-PCR检测阳性。我们比较和对比了这种新型冠状病毒和SARS冠状病毒的临床表现、实验室诊断和感染处理，尽管关于前者的公开信息很少。由于70%的新出现的传染病病原体来自动物，这种新病毒的出现可能代表了贝塔冠状病毒从动物到人类的又一次物种跳跃，类似于19世纪90年代可能来自牛的A组冠状病毒OC43和2003年B组SARS冠状病毒从蝙蝠向果子狸和人类的跳跃。尽管现阶段病毒的传播力明显较低，但针对另一场类似SARS的大流行的研究准备是一项重要的预防战略。
Fouchier et al. reported the isolation and genome sequencing of a novel coronavirus tentatively named “human betacoronavirus 2c EMC/2012 (HCoV-EMC)” from a Saudi patient presenting with pneumonia and renal failure in June 2012. Genome sequencing showed that this virus belongs to the group C species of the genus betacoronavirus and phylogenetically related to the bat coronaviruses HKU4 and HKU5 previously found in lesser bamboo bat and Japanese Pipistrelle bat of Hong Kong respectively. Another patient from Qatar with similar clinical presentation and positive RT-PCR test was reported in September 2012. We compare and contrast the clinical presentation, laboratory diagnosis and management of infection due to this novel coronavirus and that of SARS coronavirus despite the paucity of published information on the former. Since 70% of all emerging infectious pathogens came from animals, the emergence of this novel virus may represent another instance of interspecies jumping of betacoronavirus from animals to human similar to the group A coronavirus OC43 possibly from a bovine source in the 1890s and the group B SARS coronavirus in 2003 from bat to civet and human. Despite the apparently low transmissibility of the virus at this stage, research preparedness against another SARS-like pandemic is an important precautionary strategy.
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影响因子：
19.6
作者：
Chu KH;Tsang WK;Tang CS;Lam MF;Lai FM;To KF;Fung KS;Tang HL;Yan WW;Chan HW;Lai TS;Tong KL;Lai KN
通讯作者：
Lai KN
影响因子：
9.4
作者：
Che, XY;Qiu, LW;Yuen, KY
通讯作者：
Yuen, KY
DOI：
10.1007/s10096-004-1271-9
发表时间：
2005-01
期刊：
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
影响因子：
--
作者：
Cheng Y;Wong R;Soo YO;Wong WS;Lee CK;Ng MH;Chan P;Wong KC;Leung CB;Cheng G
通讯作者：
Cheng G
DOI：
10.1016/s0140-6736(04)16255-7
发表时间：
2004-05-22
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cheng PK;Wong DA;Tong LK;Ip SM;Lo AC;Lau CS;Yeung EY;Lim WW
通讯作者：
Lim WW
影响因子：
13.5
作者：
Chau, TN;Lee, KC;Lai, CL
通讯作者：
Lai, CL