Serum non-high-density lipoprotein cholesterol concentration and risk of death from cardiovascular diseases among U.S. adults with diagnosed diabetes: the Third National Health and Nutrition Examination Survey linked mortality study.
Serum non-high-density lipoprotein cholesterol concentration and risk of death from cardiovascular diseases among U.S. adults with diagnosed diabetes: the Third National Health and Nutrition Examination Survey linked mortality study.
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血清非密度脂蛋白胆固醇浓度和患有诊断糖尿病的成年人心血管疾病的死亡风险：第三次全国性健康和营养检查调查调查链接死亡率研究。
DOI：
10.1186/1475-2840-10-46
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发表时间：
2011-05-23
影响因子：
9.3
通讯作者：
Gidding SS
中科院分区：
文献类型：
--
作者：
Li C;Ford ES;Tsai J;Zhao G;Balluz LS;Gidding SS
非高密度脂蛋白胆固醇（non-HDL-C）测量所有致动脉粥样硬化载脂蛋白b含脂蛋白和预测心血管疾病（CVD）的风险。非hdl - c与糖尿病患者心血管疾病死亡风险的关系尚不清楚。该研究评估了一种假设，即在成人糖尿病患者中，非hdl - c可能与心血管疾病死亡风险有关。我们分析了参加第三次全国健康和营养检查调查相关死亡率研究的1,122名20岁及以上诊断为糖尿病的成年人的数据（299例根据潜在死因死于心血管疾病，中位随访时间为12.4年）。与血清非hdl - c浓度为35 - 129 mg/dL的参与者相比，血清非hdl - c浓度较高的参与者死于总心血管疾病的风险更高：在调整人口统计学特征和选择的危险因素后，非hdl - c浓度为130-189 mg/dL和190-403 mg/dL的rr分别为1.34 （95% CI: 0.75-2.39）和2.25 (95% CI: 1.30-3.91)（线性趋势P = 0.003）。在亚组分析中，发现缺血性心脏病死亡风险的显著线性趋势：相对危险度分别为1.59 （95% CI: 0.76-3.32）和2.50 (95% CI: 1.28-4.89)（线性趋势P = 0.006），卒中的相对危险度分别为3.37 （95% CI: 0.95-11.90）和5.81 (95% CI: 1.96-17.25)（线性趋势P = 0.001）。在糖尿病患者中，较高的血清非hdl - c浓度与心血管疾病死亡风险增加显著相关。我们的前瞻性数据支持这样一种观点，即降低血清非hdl - c浓度可能有利于预防受影响成人心血管疾病的过度死亡。
Non-high-density lipoprotein cholesterol (non-HDL-C) measures all atherogenic apolipoprotein B-containing lipoproteins and predicts risk of cardiovascular diseases (CVD). The association of non-HDL-C with risk of death from CVD in diabetes is not well understood. This study assessed the hypothesis that, among adults with diabetes, non-HDL-C may be related to the risk of death from CVD. We analyzed data from 1,122 adults aged 20 years and older with diagnosed diabetes who participated in the Third National Health and Nutrition Examination Survey linked mortality study (299 deaths from CVD according to underlying cause of death; median follow-up length, 12.4 years). Compared to participants with serum non-HDL-C concentrations of 35 to 129 mg/dL, those with higher serum levels had a higher risk of death from total CVD: the RRs were 1.34 (95% CI: 0.75-2.39) and 2.25 (95% CI: 1.30-3.91) for non-HDL-C concentrations of 130-189 mg/dL and 190-403 mg/dL, respectively (P = 0.003 for linear trend) after adjustment for demographic characteristics and selected risk factors. In subgroup analyses, significant linear trends were identified for the risk of death from ischemic heart disease: the RRs were 1.59 (95% CI: 0.76-3.32) and 2.50 (95% CI: 1.28-4.89) (P = 0.006 for linear trend), and stroke: the RRs were 3.37 (95% CI: 0.95-11.90) and 5.81 (95% CI: 1.96-17.25) (P = 0.001 for linear trend). In diabetics, higher serum non-HDL-C concentrations were significantly associated with increased risk of death from CVD. Our prospective data support the notion that reducing serum non-HDL-C concentrations may be beneficial in the prevention of excess death from CVD among affected adults.
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影响因子：
11.1
作者：
Holme, I.;Aastveit, A. H.;Walldius, G.
通讯作者：
Walldius, G.
影响因子：
9.3
作者：
Hermans MP;Sacks FM;Ahn SA;Rousseau MF
通讯作者：
Rousseau MF
影响因子：
2.8
作者：
Farwell, WR;Sesso, HD;Gaziano, JM
通讯作者：
Gaziano, JM
影响因子：
9.9
作者：
Kurth, T.;Everett, B. M.;Gaziano, J. M.
通讯作者：
Gaziano, J. M.
影响因子：
--
作者：
Cui, YD;Blumenthal, RS;Bush, TL
通讯作者：
Bush, TL