Risk factors and prognosis of liver metastasis in gallbladder cancer patients: A SEER-based study.
Risk factors and prognosis of liver metastasis in gallbladder cancer patients: A SEER-based study.
复制标题
胆囊癌患者肝转移的危险因素和预后：一项基于SEER的研究
DOI：
10.3389/fsurg.2022.899896
复制
发表时间：
2022
影响因子：
1.8
通讯作者：
Chen, Yong
中科院分区：
文献类型：
--
作者：
Fang, Cheng;Li, Wenhui;Wang, Qingqiang;Wang, Ruoran;Dong, Hui;Chen, Junjie;Chen, Yong
肝转移是胆囊癌的常见并发症。我们设计了这项研究，以开发预测GBC患者肝转移发展的模型，并评估这些肝转移患者的死亡风险。这项研究包括2010至2016年间来自监测流行病学和最终结果(SEER)的GBC患者。应用Logistic回归分析发现危险因素并构建预测GBC患者肝转移的模型。采用COX回归分析GBC肝转移患者的死亡危险因素。通过计算接收器工作特性曲线下面积(AUC)来评估所构建的预测模型的性能。多因素Logistic回归分析显示，T分期、N分期和肿瘤分级是影响GBC患者肝转移的危险因素。由这些因素组成的预测肝转移发展的模型在训练队列和测试队列中的AUC分别为0.707和0.657。多因素COX回归分析显示，原发灶的手术和化疗与GBC肝转移患者的死亡率独立相关。由这两个因素组成的肝转移患者1年死亡率预测模型在训练队列和测试队列中的AUC分别为0.734和0.776。我们构建的预测模型有助于外科医生评估GBC患者的肝转移风险和肝转移患者的生存状况。有肝转移的胆囊癌应行原发灶手术和化疗。
Liver metastasis is a common complication in gallbladder cancer (GBC). We design this study to develop models for predicting the development of liver metastasis in GBC patients and evaluate the risk of mortality in these patients with liver metastasis. GBC patients from Surveillance Epidemiology and End Results (SEER) between 2010 and 2016 were included in this study. Logistic regression was performed to discover risk factors and construct predictive models for liver metastasis in GBC patients. Cox regression was utilized to find risk factors of mortality in GBC patients with liver metastasis. The area under the receiver operating characteristic curve (AUC) was calculated to evaluate the performance of the constructed predictive models. Multivariate logistic regression confirmed that T stage, N stage, and tumor grade were risk factors for liver metastasis in GBC patients. Composed of these factors, the model for predicting the development of liver metastasis had AUCs of 0.707 and 0.657 in the training cohort and testing cohort, respectively. Multivariate Cox regression showed that surgery of the primary site and chemotherapy were independently associated with the mortality of GBC patients with liver metastasis. Composed of these two factors, the predictive model for 1-year mortality of GBC patients with liver metastasis had AUCs of 0.734 and 0.776 in the training cohort and testing cohort, respectively. The predictive models that we constructed are helpful for surgeons to evaluate the risk of liver metastasis in GBC patients and the survival condition of those with liver metastasis. Surgery of the primary site and chemotherapy should be provided for GBC with liver metastasis.
登录
查看更多内容
影响因子：
3.6
作者：
Cai, Yu-Long;Lin, Yi-Xin;Cheng, Nan-Sheng
通讯作者：
Cheng, Nan-Sheng
影响因子：
2.9
作者：
Lim, Hyun;Seo, Dong Wan;Hwang, Shin
通讯作者：
Hwang, Shin
影响因子：
2.9
作者：
Butte, Jean M.;Goenen, Mithat;Jarnagin, William R.
通讯作者：
Jarnagin, William R.
影响因子：
2.9
作者：
Mady, Mohamed;Prasai, Kritika;Mahipal, Amit
通讯作者：
Mahipal, Amit
影响因子：
1.9
作者：
Yang Y;Tu Z;Ye C;Cai H;Yang S;Chen X;Tu J
通讯作者：
Tu J