An integrative analysis of the age-associated multi-omic landscape across cancers.
An integrative analysis of the age-associated multi-omic landscape across cancers.
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DOI：
10.1038/s41467-021-22560-y
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发表时间：
2021-04-20
影响因子：
16.6
通讯作者：
de Magalhães JP
中科院分区：
文献类型：
--
作者：
Chatsirisupachai K;Lesluyes T;Paraoan L;Van Loo P;de Magalhães JP
年龄是癌症最重要的危险因素，因为癌症发病率和死亡率随着年龄的增长而增加。然而，不同年龄患者的肿瘤分子改变有何不同仍有待探索。在这里，我们利用癌症基因组图谱的数据，全面描述了与不同癌症类型患者年龄相关的基因组、转录组和表观遗传改变。我们发现，老年患者的肿瘤呈现出基因组不稳定性、体细胞拷贝数改变（SCNA）和体细胞突变的总体增加。在不同癌症类型的多个癌症驱动基因中发现了与年龄相关的 SCNA 和突变。与年龄相关的最大基因组差异存在于神经胶质瘤和子宫内膜癌中。我们确定了与年龄相关的整体转录组变化，并证明这些基因部分受到与年龄相关的 DNA 甲基化变化的调节。这项研究提供了与年龄相关的癌症改变的全面、多组学观点，并强调年龄是癌症研究和临床实践中需要考虑的重要因素。我们对癌症中与年龄相关的分子改变的了解仍然有限。在这里，作者对与年龄相关的基因组、转录组和表观遗传改变进行了泛癌分析，将年龄相关的基因表达变化与年龄相关的 DNA 甲基化改变联系起来
Age is the most important risk factor for cancer, as cancer incidence and mortality increase with age. However, how molecular alterations in tumours differ among patients of different age remains largely unexplored. Here, using data from The Cancer Genome Atlas, we comprehensively characterise genomic, transcriptomic and epigenetic alterations in relation to patients’ age across cancer types. We show that tumours from older patients present an overall increase in genomic instability, somatic copy-number alterations (SCNAs) and somatic mutations. Age-associated SCNAs and mutations are identified in several cancer-driver genes across different cancer types. The largest age-related genomic differences are found in gliomas and endometrial cancer. We identify age-related global transcriptomic changes and demonstrate that these genes are in part regulated by age-associated DNA methylation changes. This study provides a comprehensive, multi-omics view of age-associated alterations in cancer and underscores age as an important factor to consider in cancer research and clinical practice. Our understanding of the age-related molecular alterations in cancer is still limited. Here, the authors perform a pan-cancer analysis of age-associated genomic, transcriptomic, and epigenetic alterations, linking age-related gene expression changes to age-related DNA methylation alterations
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影响因子：
16.6
作者：
Chatsirisupachai K;Lesluyes T;Paraoan L;Van Loo P;de Magalhães JP
通讯作者：
de Magalhães JP
影响因子：
5.8
作者：
Gu, Zuguang;Eils, Roland;Schlesner, Matthias
通讯作者：
Schlesner, Matthias
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
14.9
作者：
Colaprico A;Silva TC;Olsen C;Garofano L;Cava C;Garolini D;Sabedot TS;Malta TM;Pagnotta SM;Castiglioni I;Ceccarelli M;Bontempi G;Noushmehr H
通讯作者：
Noushmehr H
影响因子：
50.3
作者：
Berger AC;Korkut A;Kanchi RS;Hegde AM;Lenoir W;Liu W;Liu Y;Fan H;Shen H;Ravikumar V;Rao A;Schultz A;Li X;Sumazin P;Williams C;Mestdagh P;Gunaratne PH;Yau C;Bowlby R;Robertson AG;Tiezzi DG;Wang C;Cherniack AD;Godwin AK;Kuderer NM;Rader JS;Zuna RE;Sood AK;Lazar AJ;Ojesina AI;Adebamowo C;Adebamowo SN;Baggerly KA;Chen TW;Chiu HS;Lefever S;Liu L;MacKenzie K;Orsulic S;Roszik J;Shelley CS;Song Q;Vellano CP;Wentzensen N;Cancer Genome Atlas Research Network;Weinstein JN;Mills GB;Levine DA;Akbani R
通讯作者：
Akbani R