Genetic polymorphisms and erythrocyte sodium-lithium countertransport in essential hypertension.
Genetic polymorphisms and erythrocyte sodium-lithium countertransport in essential hypertension.
复制标题
原发性高血压的遗传多态性和红细胞钠锂反转运。
DOI：
10.1016/0009-8981(96)06389-9
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
D. Clement
中科院分区：
文献类型：
--
作者：
K. Tournoy;J. Delanghe;D. Duprez;M. D. De Buyzere;R. Verbeeck;D. Vergauwe;G. Leroux;D. Clement
高血压病患者红细胞钠-锂逆向转运(SLC)活性升高。随着人们对与高血压相关的生化指标紊乱的遗传基础的日益关注，我们对调节SLC的关键基因尤其感兴趣，这可能与原发性动脉高血压的病理生理有关。因此，本研究的目的是探讨原发性高血压的SLC及其决定因素。研究结合珠蛋白(Hp)、血管紧张素转换酶(ACE-I/D)插入/缺失多态和MNS血型系统对SLC调节的影响。在一项横断面病例对照研究中对SLC活性进行了研究，研究对象包括90名高加索人：60名治疗至少一年的原发性高血压患者和30名正常血压对照组。高血压病患者SLC活性显著高于对照组(P=0.00005)。在血压正常的患者中，所研究的不同多态在SLC中没有观察到差异。而高血压组HP2-1表型SLC活性较高(P=0.003)，且与ACEI/D基因分型和MNS血型多态无关。多因素方差分析显示，HP2-1表型存在与否和体重对SLC活性的影响有统计学意义(P=0.001)。多因素回归分析显示，相同的参数是高血压病患者SLC的独立决定因素。SLC活性与靶器官损害无相关性，靶器官损害包括冠状动脉疾病、外周动脉闭塞疾病、左心室肥厚和脑血管意外。我们得出结论，尽管降压治疗，红细胞SLC活性仍升高。在高血压病患者中，HP2-1表型个体的SLC活性高于其他HP型个体，提示高血压病患者存在遗传异质性。HP2-1表型的存在与否是SLC活性的独立决定因素，而体重共同决定了高血压病患者的SLC活性。
Erythrocyte sodium-lithium countertransport (SLC) activity is elevated in essential arterial hypertension. With the growing attention to the genetic substrate of disturbed biochemical tests associated with essential arterial hypertension, we were particularly interested in the involvement of key genes for the regulation of SLC, possibly related to the pathophysiology of essential arterial hypertension. Consequently, the aim of the present study was to investigate SLC and its determining factors in essential hypertension. The influence of haptoglobin (Hp)-polymorphism, insertion/deletion polymorphism of angiotensin converting enzyme (ACE-I/D) and MNS blood group system on the regulation of SLC was studied. SLC activity was studied in a cross-sectional case-control study including 90 Caucasians: 60 patients with essential arterial hypertension who had been treated for at least 1 year and 30 normotensive controls. In essential hypertension, the SLC activity is significantly higher (P = 0.00005) than in controls. In normotensive patients, no differences in SLC are observed for the different polymorphisms studied. However, in the hypertensive group, SLC activity is higher (P = 0.003) in Hp 2-1 phenotype and independent of ACE-I/D genotyping and MNS blood group polymorphism. Multifactor analysis of variance in essential hypertension reveals significant (P = 0.001) differences in SLC activity for the presence or absence of Hp 2-1 phenotype and for body weight (P = 0.0003). Multivariate regression analysis shows the same parameters to be independent determining factors of SLC in essential arterial hypertension. No relation is found between SLC activity and target organ damage which includes coronary artery disease, peripheral arterial occlusive disease, left ventricular hypertrophy and cerebrovascular accident. We conclude that erythrocyte SLC activity is elevated despite pressure-lowering therapy. In essential arterial hypertension, individuals of Hp 2-1 phenotype show higher SLC activity than patients of other Hp-types, suggesting genetic heterogeneity of essential arterial hypertension. The presence or absence of Hp 2-1 phenotype is an independent determining factor of SLC activity whereas body weight codetermines SLC activity in essential hypertension.
影响因子：
9.8
作者：
L. Tiret;B. Rigat;S. Visvikis;C. Breda;P. Corvol;F. Cambien;F. Soubrier
通讯作者：
L. Tiret;B. Rigat;S. Visvikis;C. Breda;P. Corvol;F. Cambien;F. Soubrier
5 至 89 岁白种人钠锂逆转运和血压的分布。
DOI：
10.1161/01.hyp.13.4.378
发表时间：
1989
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Turner,ST;Weidman,WH;Michels,VV;Reed,TJ;Ormson,CL;Fuller,T;Sing,CF
通讯作者：
Sing,CF
触珠蛋白与钠敏感性和血压抵抗力的关联。
DOI：
10.1161/01.hyp.10.4.443
发表时间：
1987
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Weinberger,MH;Miller,JZ;Fineberg,NS;Luft,FC;Grim,CE;Christian,JC
通讯作者：
Christian,JC