Amygdala hyperactivation in untreated depressed individuals.
Amygdala hyperactivation in untreated depressed individuals.
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DOI：
10.1016/j.pscychresns.2009.03.006
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发表时间：
2009-08-30
影响因子：
2.3
通讯作者：
Soares, Jair C.
中科院分区：
文献类型：
--
作者：
Peluso, Marco A. M.;Glahn, David C.;Matsuo, Koji;Monkul, E. Serap;Najt, Pablo;Zamarripa, Frank;Li, Jinqi;Lancaster, Jack L.;Fox, Peter T.;Gao, Jia-Hong;Soares, Jair C.
杏仁核参与情感状态的检测和控制，并被认为是情感障碍中功能障碍的部位。为了评估单相抑郁症患者的杏仁核处理过程，我们应用了功能性 MRI (fMRI) 范式，该范式先前被证明对杏仁核功能敏感。使用功能磁共振成像和标准化情绪面部识别任务对 14 名未经治疗的 DSM-IV 重度抑郁症患者和 15 名健康受试者进行了研究。对体素级数据集进行多重回归分析，并使用多元方差分析对功能定义的感兴趣区域 (ROI)（包括双侧杏仁核）进行分析。还计算了杏仁核激活和 HAM-D 评分之间的 Pearson 相关系数。与几何形状相比，抑郁症组和健康组在观看情绪面孔时都表现出杏仁核活动增加，但单相抑郁症患者比健康受试者表现出相对更多的活动，尤其是左侧。在患者组的左右 ROI 中发现杏仁核激活与 HAM-D 评分之间存在 Pearson 正相关性。这项研究提供了体内成像证据来支持抑郁症个体杏仁核功能异常的假设。
The amygdala participates in the detection and control of affective states, and has been proposed to be a site of dysfunction in affective disorders. To assess amygdala processing in individuals with unipolar depression, we applied a functional MRI (fMRI) paradigm previously shown to be sensitive to amygdala function. Fourteen individuals with untreated DSM-IV major depression and 15 healthy subjects were studied using fMRI with a standardized emotion face recognition task. Voxel-level data sets were subjected to a multiple-regression analysis, and functionally defined regions of interest (ROI), including bilateral amygdala, were analyzed with MANOVA. Pearson correlation coefficients between amygdala activation and HAM-D score also were performed. While both depressed and healthy groups showed increased amygdala activity when viewing emotive faces compared to geometric shapes, patients with unipolar depression showed relatively more activity than healthy subjects, particularly on the left. Positive Pearson correlations between amygdala activation and HAM-D score were found for both left and right ROIs in the patient group. This study provides in vivo imaging evidence to support the hypothesis of abnormal amygdala functioning in depressed individuals.
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