Intratumoral expression of IL-17 and its prognostic role in gastric adenocarcinoma patients.
Intratumoral expression of IL-17 and its prognostic role in gastric adenocarcinoma patients.
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DOI：
10.7150/ijbs.7.53
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发表时间：
2011-01-11
影响因子：
9.2
通讯作者：
Li Q
中科院分区：
文献类型：
--
作者：
Chen JG;Xia JC;Liang XT;Pan K;Wang W;Lv L;Zhao JJ;Wang QJ;Li YQ;Chen SP;He J;Huang LX;Ke ML;Chen YB;Ma HQ;Zeng ZW;Zhou ZW;Chang AE;Li Q
本研究通过检测胃腺癌患者术后肿瘤组织中IL-17和CD8+TIL的表达，探讨胃腺癌患者生存概率与肿瘤组织中IL-17表达的相关性。用免疫组织化学方法检测IL-17和CD8的表达，用Cox回归和Kaplan-Meier分析评价IL-17表达和CD8+TIL对预后的影响。免疫组织化学检测显示胃腺癌组织中IL-17和CD8+细胞阳性率分别为90.6%(174/192)和96.9%(186/192)。IL-17的表达与年龄显著相关(p=0.004)，CD8+TIL的数量与UICC分期(p=0.012)和肿瘤侵袭深度(p=0.022)显著相关。在肿瘤内表达较高水平的IL-17的患者的五年总生存概率明显好于表达较低水平的IL-17的患者(p=0.036)。多变量COX比例风险分析显示，肿瘤内IL-17的表达(HR：0.521；95%CI：0.329-0.823；P=0.005)是影响五年总生存概率的独立因素。我们的结论是，肿瘤内IL-17的低水平表达可能预示着胃腺癌患者预后不良。
In this study, we characterized the intratumoral expression of IL-17 and CD8+ TILs in gastric adenocarcinoma patients after resection and determined the correlation between the survival probability of gastric adenocarcinoma patients and the expression of IL-17 in tumor. Expression of IL-17 and CD8 was assessed by immunohistochemistry, and the prognostic effects of intratumoral IL-17 expression and CD8+ TILs were evaluated by Cox regression and Kaplan-Meier analysis. Immunohistochemical detection revealed the presence of IL-17 and CD8+ cells in gastric adenocarcinoma tissue samples (90.6%, 174 out of 192 patients and 96.9%, 186 out of 192 patients, respectively). We have also found that intratumoral IL-17 expression was significantly correlated with age (p=0.004) and that the number of CD8+ TILs was significantly correlated with UICC staging (p=0.012) and the depth of tumor invasion (p=0.022). The five-year overall survival probability among patients intratumorally expressing higher levels of IL-17 was significantly better than those expressing lower levels of IL-17 (p=0.036). Multivariate Cox proportional hazard analyses revealed that intratumoral IL-17 expression (HR: 0.521; 95% CI: 0.329-0.823; p=0.005) was an independent factor affecting the five-year overall survival probability. We conclude that low levels of intratumoral IL-17 expression may indicate poor prognosis in gastric adenocarcinoma patients.
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影响因子：
11.5
作者：
Sfanos, Karen Sandell;Bruno, Tullia C.;Drake, Charles G.
通讯作者：
Drake, Charles G.
影响因子：
20.3
作者：
Kryczek, Ilona;Banerjee, Mousumi;Zou, Weiping
通讯作者：
Zou, Weiping
影响因子：
4.4
作者：
Kryczek, Ilona;Wei, Shuang;Zou, Weiping
通讯作者：
Zou, Weiping
DOI：
10.4049/jimmunol.0902574
发表时间：
2010-03-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
He D;Li H;Yusuf N;Elmets CA;Li J;Mountz JD;Xu H
通讯作者：
Xu H
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P