White matter microstructure and atypical visual orienting in 7-month-olds at risk for autism.
White matter microstructure and atypical visual orienting in 7-month-olds at risk for autism.
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DOI：
10.1176/appi.ajp.2012.12091150
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发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
IBIS Network
中科院分区：
文献类型：
--
作者：
Elison JT;Paterson SJ;Wolff JJ;Reznick JS;Sasson NJ;Gu H;Botteron KN;Dager SR;Estes AM;Evans AC;Gerig G;Hazlett HC;Schultz RT;Styner M;Zwaigenbaum L;Piven J;IBIS Network
作者试图确定7个月大的婴儿是否具有特定的眼球运动功能和视觉定向模式，这些婴儿后来符合自闭症谱系障碍(ASD)的标准，并确定这些行为的神经相关性。收集了97名婴儿的数据，其中16名是后来被归类为患有ASD的高家族风险婴儿，40名是后来不符合ASD标准(高风险阴性)的高家族风险婴儿，41名是低风险婴儿。所有婴儿在平均年龄7个月时接受了眼球跟踪任务，并在平均25个月时进行了临床评估。其中84名婴儿在7个月时获得了弥散加权成像数据。主要观察指标包括在视觉引导的眼跳过程中的平均眼跳反应时间和纤维束中的径向弥散率(白质组织的一个指数)，包括皮质脊髓通路和胼胝体压部和膝部。与高危阴性婴儿和低风险婴儿相比，在25个月时表现出ASD症状的7个月大婴儿的视觉定向潜伏期更长。在低风险婴儿中，视觉定向潜伏期与穹窿体压部的微结构组织有独特的联系，但这种联系在后来被归类为ASD的婴儿中并不明显。灵活而有效地定位于环境中的显著信息对随后的认知和社会认知发展至关重要。非典型视觉定向可能代表ASD的早期先兆特征，后皮质环路的异常功能特化直接为ASD的发病机制提供了一个新的模型。
The authors sought to determine whether specific patterns of oculomotor functioning and visual orienting characterize 7-month-old infants who later meet criteria for an autism spectrum disorder (ASD) and to identify the neural correlates of these behaviors. Data were collected from 97 infants, of whom 16 were high-familial-risk infants later classified as having an ASD, 40 were high-familial-risk infants who did not later meet ASD criteria (high-risk negative), and 41 were low-risk infants. All infants underwent an eye-tracking task at a mean age of 7 months and a clinical assessment at a mean age of 25 months. Diffusion-weighted imaging data were acquired for 84 of the infants at 7 months. Primary outcome measures included average saccadic reaction time in a visually guided saccade procedure and radial diffusivity (an index of white matter organization) in fiber tracts that included corticospinal pathways and the splenium and genu of the corpus callosum. Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants. Visual orienting latencies were uniquely associated with the microstructural organization of the splenium of the corpus callosum in low-risk infants, but this association was not apparent in infants later classified as having an ASD. Flexibly and efficiently orienting to salient information in the environment is critical for subsequent cognitive and social-cognitive development. Atypical visual orienting may represent an early prodromal feature of an ASD, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.
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影响因子：
34.7
作者：
Leppanen, Jukka M.;Nelson, Charles A.
通讯作者：
Nelson, Charles A.
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M
DOI：
10.1016/j.cub.2011.12.056
发表时间：
2012-02-21
期刊：
Current biology : CB
影响因子：
--
作者：
Elsabbagh M;Mercure E;Hudry K;Chandler S;Pasco G;Charman T;Pickles A;Baron-Cohen S;Bolton P;Johnson MH;BASIS Team
通讯作者：
BASIS Team
影响因子：
2.6
作者：
Colombo, J;Shaddy, DJ;Blaga, OM
通讯作者：
Blaga, OM
影响因子：
5.7
作者：
Goodlett CB;Fletcher PT;Gilmore JH;Gerig G
通讯作者：
Gerig G