Group analysis of DTI fiber tract statistics with application to neurodevelopment.
Group analysis of DTI fiber tract statistics with application to neurodevelopment.
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DOI：
10.1016/j.neuroimage.2008.10.060
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发表时间：
2009-03
期刊：
影响因子：
5.7
通讯作者：
Gerig G
中科院分区：
文献类型：
--
作者：
Goodlett CB;Fletcher PT;Gilmore JH;Gerig G
扩散张量成像(DTI)提供了体内脑白质潜在组织结构的独特信息源，包括主要纤维束的几何形状以及由派生张量测量表示的组织特性的定量信息。本文提出了一种统计比较扩散张量图像总体间纤维束扩散特性的方法。无偏微分同胚图集用于计算扩散图像总体的归一化坐标系。每个受试者和地图集之间的微分同形变换为区域统计比较提供了空间归一化。沿纤维束的扩散特性，如分数各向异性(FA)和张量范数，被建模为弧长的多元函数。假设检验是使用基于霍特林T2统计量的置换检验非参数地执行的。嵌入T2度量中的线性判别式提供了对检测到的差异的直观、局部化的解释。所提出的方法在两项神经发育的临床研究中进行了测试。在对一岁和两岁受试者的研究中，在几个区域发现FA显著增加，而Frobenius标准显著降低。在对照组和单纯性轻度脑室肥大(MVM)受试者之间的新生儿压束中发现了显着的差异，证明了这种方法在临床研究中的潜力。
Diffusion tensor imaging (DTI) provides a unique source of information about the underlying tissue structure of brain white matter in vivo including both the geometry of major fiber bundles as well as quantitative information about tissue properties represented by derived tensor measures. This paper presents a method for statistical comparison of fiber bundle diffusion properties between populations of diffusion tensor images. Unbiased diffeomorphic atlas building is used to compute a normalized coordinate system for populations of diffusion images. The diffeomorphic transformations between each subject and the atlas provide spatial normalization for the comparison of tract statistics. Diffusion properties, such as fractional anisotropy (FA) and tensor norm, along fiber tracts are modeled as multivariate functions of arc length. Hypothesis testing is performed non-parametrically using permutation testing based on the Hotelling T2 statistic. The linear discriminant embedded in the T2 metric provides an intuitive, localized interpretation of detected differences. The proposed methodology was tested on two clinical studies of neurodevelopment. In a study of one and two year old subjects, a significant increase in FA and a correlated decrease in Frobenius norm was found in several tracts. Significant differences in neonates were found in the splenium tract between controls and subjects with isolated mild ventriculomegaly (MVM) demonstrating the potential of this method for clinical studies.
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影响因子：
5.7
作者：
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通讯作者：
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DOI：
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发表时间：
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