Micro total analysis systems: fundamental advances and biological applications.
Micro total analysis systems: fundamental advances and biological applications.
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DOI：
10.1021/ac403688g
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发表时间：
2014-01-07
影响因子：
7.4
通讯作者：
Pressnall, Melissa
中科院分区：
文献类型：
--
作者：
Culbertson, Christopher T.;Mickleburgh, Tom G.;Stewart-James, Samantha A.;Sellens, Kathleen A.;Pressnall, Melissa
微全分析系统（μTAS）的研究已有20多年的历史。这些设备的最初报告，通常也被称为芯片实验室（labchip），实验室芯片，微芯片或微流体设备，通常集中在分离和开发的各种功能元件的样品操作和处理。然而，μTAS最大的潜力之一始终是集成多个功能元件，以产生真正的采样/应答系统。在过去的十年中，开发这种集成器件的步伐显著加快。现在报道的许多μTAS都非常复杂，具有高度集成且通常自动化的多个样品处理和处理步骤。虽然这些设备中的大多数还没有严格的采样/应答，但有几个已经非常接近了。然而，真正的样品输入/应答系统的发展仍然面临一些重大障碍，特别是在样品制备、芯片与真实世界的接口和检测等领域。
It has been more than 20 years since the first micro total analysis systems (μTAS) papers were published. Initial reports of these devices, which are also commonly referred to as laboratories-on-a-chip (LOC), labchips, microchips, or microfluidic devices, generally focused on separations and the development of a variety of functional elements for sample manipulation and handling. One of the greatest potentials of μTAS, however, has always been in the integration of multiple functional elements to produce truly sample-in/answer-out systems. In the past decade, the march toward developing such integrated devices has accelerated significantly. Many μTAS reported now are quite sophisticated with multiple sample handling and processing steps that are highly integrated and often automated. While most of these devices are not yet strictly sample-in/answer-out, several come quite close. There are, however, some significant hurdles still facing the development of true sample-in/answer-out systems, especially in the areas of sample preparation, chip-to-real-world interfacing, and detec-
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影响因子：
6.1
作者：
Adler M;Erickstad M;Gutierrez E;Groisman A
通讯作者：
Groisman A
影响因子：
6.1
作者：
Benz, Christian;Retzbach, Heiko;Belder, Detlev
通讯作者：
Belder, Detlev
影响因子：
15.1
作者：
Burlage, K.;Gerhardy, C.;Schomburg, W. K.
通讯作者：
Schomburg, W. K.
影响因子：
6.1
作者：
Benítez JJ;Topolancik J;Tian HC;Wallin CB;Latulippe DR;Szeto K;Murphy PJ;Cipriany BR;Levy SL;Soloway PD;Craighead HG
通讯作者：
Craighead HG
DOI：
10.1039/c2an36171j
发表时间：
2013-01-07
期刊：
The Analyst
影响因子：
--
作者：
Anderson KB;Halpin ST;Johnson AS;Martin RS;Spence DM
通讯作者：
Spence DM