Homocysteine and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis.
Homocysteine and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis.
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DOI：
10.1016/j.hlc.2018.03.007
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Folsom AR
中科院分区：
文献类型：
--
作者：
Kubota Y;Alonso A;Heckbert SR;Norby FL;Folsom AR
虽然许多研究已经调查了血同型半胱氨酸与主要心血管疾病如冠心病和中风的关系，但关于其与心房颤动（AF）的关系的研究很少。我们分析了来自社区动脉粥样硬化风险研究（ARIC）（n=492，年龄45-64岁）和多种族动脉粥样硬化研究（梅萨）（n=6641，年龄45-84岁）的数据。在10，106和67，613人年的随访期间，我们分别在ARIC和梅萨中发现了85和351例AF事件。年龄、性别和人种校正模型显示，ARIC和梅萨患者血浆同型半胱氨酸浓度与AF发生率之间存在剂量反应关系。对其他房颤风险因素的进一步调整并没有改变相关性。在完全校正模型中，两项研究的荟萃分析显示同型半胱氨酸与AF之间存在显著相关性[log 2（同型半胱氨酸）每1单位增量的风险比（95%置信区间），1.27（1.01-1.61）]。所有三种B族维生素（维生素B6和B12以及叶酸）水平较高的个体患AF的风险较低，但这些相关性在统计学上并不显著。在整个ARIC队列中[n= 12，686（2079例AF事件）]，C677 T亚甲基四氢叶酸还原酶（MTHFR）突变与AF之间没有关联。在基于前瞻性人群的ARIC和梅萨队列中，同型半胱氨酸升高与AF事件风险增加适度相关，但C677 T MTHFR突变与AF风险无关，提示同型半胱氨酸可能是房颤的一个新的危险标志物，而不是一个因果危险因素。
Although many studies have investigated the association of blood homocysteine with major cardiovascular diseases such as coronary heart disease and stroke, researchon its association with atrial fibrillation (AF) is scarce. We analysed data from Atherosclerosis Risk in Communities (ARIC) Study (n=492, age 45–64 years) and Multi-Ethnic Study of Atherosclerosis (MESA) (n=6641, age 45–84 years). During the 10,106 and 67,613 person-years of follow-up, we identified 85 and 351 AF events in ARIC and MESA, respectively. An age-, sex-, and race-adjusted model showed dose-response relations between plasma homocysteine concentrations and AF incidence in both ARIC and MESA. Further adjustments for other AF risk factors did not change the associations. In the fully adjusted model, a meta-analysis of both studies showed a significant association between homocysteine and AF [hazard ratio (95% confidence interval) per 1 unit increment in log2(homocysteine), 1.27 (1.01–1.61)]. Individuals with higher levels of all three B vitamins (vitamin B6 and B12, and folate) had a lower risk of AF, but those associations were not statistically significant. In the full ARIC cohort [n=12,686 (2079 AF events)], there was no association between the C677T methylenetetrahydrofolate reductase (MTHFR)mutation and AF. In the prospective population-based ARIC and MESA cohorts, elevated homocysteine was modestly associated with an increased risk of incident AF, but the C677T MTHFR mutation was not associated with AF risk, suggesting that homocysteine may be a novel risk marker for AF rather than a causal risk factor.
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影响因子：
39
作者：
Kubota, Yasuhiko;Heiss, Gerardo;Folsom, Aaron R.
通讯作者：
Folsom, Aaron R.
影响因子：
37.8
作者：
Folsom, AR;Nieto, FJ;Davis, CE
通讯作者：
Davis, CE
影响因子：
10.4
作者：
Adams, N. B.;Lutsey, P. L.;Cushman, M.
通讯作者：
Cushman, M.
DOI：
10.1111/j.1440-1681.2007.04671.x
发表时间：
2007-09-01
影响因子：
2.9
作者：
Cai, Ben-Zhi;Gong, Dong-Mei;Yang, Bao-Feng
通讯作者：
Yang, Bao-Feng
DOI：
10.1016/j.jtcvs.2012.07.099
发表时间：
2013-10-01
影响因子：
6
作者：
Nasso, Giuseppe;Bonifazi, Raffaele;Speziale, Giuseppe
通讯作者：
Speziale, Giuseppe