Limb venous tone and responsiveness in hypertensive humans.
Limb venous tone and responsiveness in hypertensive humans.
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高血压患者的肢体静脉张力和反应性。
DOI：
10.1152/japplphysiol.90574.2008
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Farquhar,WilliamB
中科院分区：
文献类型：
--
作者：
Delaney,ErinP;Young,ColinN;Disabatino,Angela;Stillabower,MichaelE;Farquhar,WilliamB
与正常血压（NTN）对照相比，高血压（HTN）动物模型表现出较低的静脉顺应性以及增加的静脉张力和反应性。然而，实验动物的发现在多大程度上可以推广到人类尚不清楚。对 9 名 NTN（23 ± 1 岁）和 9 名 HTN（24 ± 1 岁）男性的前臂和小腿静脉顺应性进行了量化，这些男性在基线、给予硝酸甘油（NTG）后、冷加压试验（CP）期间和握力后运动缺血（PEI）期间。采用二次回归对袖带放气方案 (1 mmHg/s) 中的个体压力-容积关系进行建模。回归参数β1和β2用于计算依从性。使用单向方差分析来比较 β 参数，使用重复测量方差分析来比较所有压力下的体积（基线时的组间和扰动期间的组内）。各组之间的肢体静脉顺应性相似（前臂：NTN β1= 0.11 ± 0.01 和 β2= -0.00097 ± 0.0001，HTN β1= 0.10 ± 0.01 和 β2= -0.00088 ± 0.0001；小腿：NTN β1= 0.12 ± 0.01 和 β2= −0.00102 ± 0.0001，HTN β1=0.11±0.01，β2=-0.00090±0.0001）。然而，在基线时，HTN 受试者的前臂所有压力下的容量（即电容）较低 (P≤ 0.01)，小腿往往较低 (P= 0.08)。两组中的静脉顺应性均未因任何扰动而改变。仅 HTN 受试者在 NTG 期间前臂体积有所增加。虽然 NTN 和 HTN 成人之间的静脉顺应性相似，但 HTN 成人的前臂静脉容量（容量）较低，且随着 NTG 的增加而增加。这些数据表明，与 NTN 对照相比，年轻的 HTN 成年人可能具有增强的静脉平滑肌张力。
Hypertensive (HTN) animal models demonstrate lower venous compliance as well as increased venous tone and responsiveness compared with normotensive (NTN) controls. However, the extent to which findings in experimental animals can be extended to humans is unknown. Forearm and calf venous compliance were quantified in 9 NTN (23 ± 1 yr) and 9 HTN (24 ± 1 yr) men at baseline, after administration of nitroglycerin (NTG), during a cold pressor test (CP), and post-handgrip exercise ischemia (PEI). Individual pressure-volume relationships from a cuff deflation protocol (1 mmHg/s) were modeled with a quadratic regression. Regression parameters β1and β2were used to calculate compliance. A one-way ANOVA was used to compare the beta parameters and a repeated-measures ANOVA was used to compare volumes across all pressures (between groups at baseline and within groups during perturbations). Limb venous compliance was similar between groups (forearm: NTN β1= 0.11 ± 0.01 and β2= −0.00097 ± 0.0001, HTN β1= 0.10 ± 0.01 and β2= −0.00088 ± 0.0001; calf: NTN β1= 0.12 ± 0.01 and β2= −0.00102 ± 0.0001, HTN β1= 0.11 ± 0.01 and β2= −0.00090 ± 0.0001). However, at baseline, volume across all pressures (i.e., capacitance) was lower in the forearm (P≤ 0.01) and tended to be lower in the calf (P= 0.08) in HTN subjects. Venous compliance was not altered by any perturbation in either group. Forearm volume was increased during NTG in HTN subjects only. While venous compliance was similar between NTN and HTN adults, HTN adults have lower forearm venous capacitance (volume) which is increased with NTG. These data suggest that young HTN adults may have augmented venous smooth muscle tone compared with NTN controls.
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青少年直立性心动过速综合征的反射性血管缺陷。
DOI：
10.1152/jappl.2001.90.6.2025
发表时间：
2001
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Stewart,JM;Weldon,A
通讯作者：
Weldon,A
高血压大鼠静脉功能的改变
影响因子：
20.1
作者：
G. Simon
通讯作者：
G. Simon
稀释复合材料中强度依赖光学活性的理论
影响因子：
3.2
作者：
D. Stroud
通讯作者：
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Goldblatt 高血压大鼠的总静脉容量降低。
DOI：
10.1152/ajpheart.1981.240.4.h487
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
--
作者：
J. Yamamoto;N. Trippodo;A. Macphee;E. Frohlich
通讯作者：
E. Frohlich
影响因子：
8.3
作者：
PARATI, G;CASADEI, R;MANCIA, G
通讯作者：
MANCIA, G