Effects of Prenatal Micronutrient Supplementation on Spontaneous Preterm Birth: A Double-Blind Randomized Controlled Trial in China.
Effects of Prenatal Micronutrient Supplementation on Spontaneous Preterm Birth: A Double-Blind Randomized Controlled Trial in China.
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产前补充微量营养素对自然早产的影响：中国的双盲随机对照试验
DOI：
10.1093/aje/kwx094
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发表时间：
2017-08-01
影响因子：
5
通讯作者：
中科院分区：
文献类型：
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作者：
在对中国北方开展的一项双盲随机对照试验数据的二次分析中，我们旨在评估产前补充多种微量营养素（MMN）或铁+叶酸（IFA）与单独补充叶酸（FA）对自发性早产（SPB）风险的影响以及补充时间对SPB的影响。在2006年至2009年期间，共有18,775名未经产的孕妇被随机分配接受每日FA，IFA或MMN，从孕20周前到分娩。食用FA、IFA和MMN的妇女SPB发生率分别为5.7%、5.6%和5.1%。与FA组相比，MMN组和IFA组SPB的相对危险度分别为0.99（95%可信区间：0.85，1.16）和0.89（95%可信区间：0.79，1.05）。在妊娠12周之前开始服用FA，IFA和MMN的女性中SPB发生率（分别为4.6%，4.2%和3.9%）与妊娠12周或之后开始使用补充剂（分别为6.9%，7.2%和6.4%）相比显着降低。在妊娠第12周之前开始使用FA，IFA或MMN补充剂可使SPB风险降低41%-45%。早期产前登记和微量营养素的使用在怀孕的头三个月似乎是特别重要的预防SPB，无论补充组。
In this secondary analysis of data from a double-blind randomized controlled trial carried out in northern China, we aimed to assess the effect of prenatal supplementation with multiple micronutrients (MMN) or iron + folic acid (IFA), versus folic acid (FA) alone, on risk of spontaneous preterm birth (SPB) and the impact of supplementation timing on SPB. A total of 18,775 nulliparous pregnant women enrolled between 2006 and 2009 were randomly assigned to receive daily FA, IFA, or MMN from the period before 20 weeks’ gestation to delivery. The incidences of SPB for women consuming FA, IFA, and MMN were 5.7%, 5.6% and 5.1%, respectively. Compared with women given FA, the relative risks of SPB for those using MMN and IFA were 0.99 (95% confidence interval: 0.85, 1.16) and 0.89 (95% confidence interval: 0.79, 1.05), respectively. SPB incidence in women who started consuming FA, IFA, and MMN before the 12th week of gestation (4.6%, 4.2%, and 3.9%, respectively) was significantly reduced compared with starting supplement use on or after the 12th gestational week (6.9%, 7.2%, and 6.4%, respectively). Starting use of FA, IFA, or MMN supplements before the 12th week of gestation produced a 41%–45% reduction in risk of SPB. Early prenatal enrollment and micronutrient use during the first trimester of pregnancy appeared to be of particular importance for prevention of SPB, regardless of supplement group.
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DOI：
10.1186/1477-7827-10-49
发表时间：
2012-06-29
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Agarwal A;Aponte-Mellado A;Premkumar BJ;Shaman A;Gupta S
通讯作者：
Gupta S
影响因子：
2.8
作者：
Kharrazi M;Pearl M;Yang J;DeLorenze GN;Bean CJ;Callaghan WM;Grant A;Lackritz E;Romero R;Satten GA;Simhan H;Torres AR;Westover JB;Yolken R;Williamson DM
通讯作者：
Williamson DM
影响因子：
1.9
作者：
Fall CH;Fisher DJ;Osmond C;Margetts BM;Maternal Micronutrient Supplementation Study Group
通讯作者：
Maternal Micronutrient Supplementation Study Group
影响因子：
7.1
作者：
Roberfroid, Dominique;Huybregts, Lieven;Kolsteren, Patrick
通讯作者：
Kolsteren, Patrick
中国围孕叶酸补充与早产风险：一项大型前瞻性队列研究
影响因子：
7.7
作者：
Li, Zhiwen;Ye, Rongwei;Ren, Aiguo
通讯作者：
Ren, Aiguo