The effects of oxidative stress on female reproduction: a review.
The effects of oxidative stress on female reproduction: a review.
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DOI：
10.1186/1477-7827-10-49
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发表时间：
2012-06-29
期刊：
影响因子：
--
通讯作者：
Gupta S
中科院分区：
文献类型：
--
作者：
Agarwal A;Aponte-Mellado A;Premkumar BJ;Shaman A;Gupta S
氧化应激（OS）是一种以包括活性氧和氮物质的促氧化分子与抗氧化防御之间的失衡为特征的状态，已被确定在男性和女性生育力低下的发病机制中起关键作用。OS对精子质量和功能的不良影响已被充分记录。另一方面，在女性中，OS对卵母细胞和生殖功能的影响仍不清楚。这种促氧化剂和抗氧化剂之间的不平衡会导致许多生殖疾病，如子宫内膜异位症，多囊卵巢综合征（PCOS）和不明原因的不孕症。妊娠并发症，如自然流产，复发性妊娠丢失和先兆子痫，也可以在响应OS发展。研究表明，极端的体重和生活方式因素，如吸烟，饮酒和娱乐性药物的使用可以促进过量的自由基产生，这可能会影响生育能力。暴露于环境污染物越来越受到关注，因为它们也被发现会引发氧化状态，可能导致女性不育。本文将回顾目前可用的文献反应物种和OS在正常和异常的生殖生理过程中的作用。补充抗氧化剂可能有效地控制ROS的产生，并继续探索作为一种潜在的策略，以克服与不孕症相关的生殖障碍。然而，迄今为止进行的研究都是通过动物或体外研究进行的，这产生了很大程度上相互矛盾的结果。OS对辅助生殖技术（ART）的影响将得到解决，除了抗氧化剂补充ART培养基的可能好处，以增加ART成功的可能性。未来对人类的随机对照临床试验是必要的，以阐明OS影响女性生殖能力的确切机制，并将有助于进一步探索抗氧化剂治疗不孕症的可能益处。
Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility. Pregnancy complications such as spontaneous abortion, recurrent pregnancy loss, and preeclampsia, can also develop in response to OS. Studies have shown that extremes of body weight and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility. Exposures to environmental pollutants are of increasing concern, as they too have been found to trigger oxidative states, possibly contributing to female infertility. This article will review the currently available literature on the roles of reactive species and OS in both normal and abnormal reproductive physiological processes. Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. However, investigations conducted to date have been through animal or in vitro studies, which have produced largely conflicting results. The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success. Future randomized controlled clinical trials on humans are necessary to elucidate the precise mechanisms through which OS affects female reproductive abilities, and will facilitate further explorations of the possible benefits of antioxidants to treat infertility.
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影响因子：
3.8
作者：
Aris, A.;Benali, S.;Leblanc, S.
通讯作者：
Leblanc, S.
DOI：
10.1016/s0306-5456(01)00253-4
发表时间：
2001-10-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
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作者：
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