Antibiotic resistance: Global health crisis and metagenomics.
Antibiotic resistance: Global health crisis and metagenomics.
复制标题
抗生素耐药性：全球健康危机和宏基因组学。
DOI：
10.1016/j.btre.2021.e00604
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Kapley A
中科院分区：
文献类型：
--
作者：
Yadav S;Kapley A
Antimicrobial resistance is global risk to both humans & environment health. Aquatic system serves as hotspot for dissemination of AMR. Metagenomics can be used for monitoring abundance of ARGs in environment. Application of metagenomics has potential to yield novel secondary metabolites having antimicrobial potential. Antibiotic resistance is a global problem which affects human health. The imprudent use of antibiotics (medicine, agriculture, aquaculture, and food industry) has resulted in the broader dissemination of resistance. Urban wastewater & sewage treatment plants act as the hotspot for the widespread of antimicrobial resistance. Natural environment also plays an important role in the dissemination of resistance. Mapping of antibiotic resistance genes (ARGS) in environment is essential for mitigating antimicrobial resistance (AMR) widespread. Therefore, the review article emphasizes on the application of metagenomics for the surveillance of antimicrobial resistance. Metagenomics is the next generation tool which is being used for cataloging the resistome of diverse environments. We summarize the different metagenomic tools that can be used for mining of ARGs and acquired AMR present in the metagenomic data. Also, we recommend application of targeted sequencing/ capture platform for mapping of resistome with higher specificity and selectivity.
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DOI：
10.1016/j.bjm.2016.10.005
发表时间：
2016-12
期刊：
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
影响因子：
--
作者：
Braga RM;Dourado MN;Araújo WL
通讯作者：
Araújo WL
影响因子：
14.8
作者：
Chait, Remy;Vetsigian, Kalin;Kishony, Roy
通讯作者：
Kishony, Roy
影响因子：
11.8
作者：
Cheng, Weixiao;Chen, Hong;Yan, Shuhai
通讯作者：
Yan, Shuhai
影响因子：
5.2
作者：
Clausen, Philip T. L. C.;Zankari, Ea;Lund, Ole
通讯作者：
Lund, Ole
影响因子：
15.5
作者：
Arango-Argoty G;Garner E;Pruden A;Heath LS;Vikesland P;Zhang L
通讯作者：
Zhang L