The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica.
The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica.
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DOI：
10.1371/journal.pone.0035402
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Mustonen J
中科院分区：
文献类型：
--
作者：
Libraty DH;Mäkelä S;Vlk J;Hurme M;Vaheri A;Ennis FA;Mustonen J
普马拉汉坦病毒（PUUV）感染，也称为肾病，是欧洲肾综合征出血热（HFRS）最常见的原因。PUUV肾病的发病机制是复杂的和多因素的，并且在急性PUUV感染期间严重急性肾损伤（阿基）的危险因素尚未被很好地定义。我们对芬兰坦佩雷的PUUV感染住院患者进行了一项前瞻性研究，以确定HFRS严重程度的急性疾病危险因素。在整个急性疾病期间以及在2周和6个月恢复期访视时收集连续的每日血液和尿液样本。通过单变量分析，急性疾病期间的最大白色血细胞计数是重度阿基的风险因素。PUUV诱导的阿基严重程度与血小板计数、C反应蛋白或丙氨酸氨基转移酶水平之间没有显著相关性。最大血浆白细胞介素（IL）-6，尿IL-6和尿IL-8浓度与PUUV诱导的阿基呈正相关。最后，无论阿基严重程度分类如何，尿沉渣加塔-3 mRNA最大水平与血清肌酐峰值倍数变化呈正相关。通过多变量分析，我们发现急性疾病期间白细胞和尿沉渣加塔-3 mRNA的最大水平是严重PUUV诱导的阿基的独立危险因素。我们已经确定了严重PUUV诱导的阿基的新的急性疾病风险因素。
Puumala hantavirus (PUUV) infection, also known as nephropathia epidemica, is the most common cause of hemorrhagic fever with renal syndrome (HFRS) in Europe. The pathogenesis of PUUV nephropathia epidemica is complex and multifactorial, and the risk factors for severe acute kidney injury (AKI) during acute PUUV infection are not well defined. We conducted a prospective study of hospitalized patients with PUUV infection in Tampere, Finland to identify acute illness risk factors for HFRS severity. Serial daily blood and urine samples were collected throughout acute illness and at 2 week and 6 month convalescent visits. By univariate analyses, the maximum white blood cell count during acute illness was a risk factor for severe AKI. There were no significant associations between PUUV-induced AKI severity and platelet counts, C-reactive protein, or alanine aminotransferase levels. Maximum plasma interleukin (IL)-6, urine IL-6, and urine IL-8 concentrations were positively associated with PUUV-induced AKI. Finally, the maximum urinary sediment GATA-3 mRNA level was positively correlated with the peak fold-change in serum creatinine, regardless of AKI severity classification. By multivariate analyses, we found that the maximum levels of leukocytes and urinary sediment GATA-3 mRNA during acute illness were independent risk factors for severe PUUV-induced AKI. We have identified novel acute illness risk factors for severe PUUV-induced AKI.
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影响因子：
8.8
作者：
Hoffmann, SC;Hale, DA;Kirk, AD
通讯作者：
Kirk, AD
影响因子：
2.2
作者：
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作者：
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DOI：
10.1006/clin.1996.0007
发表时间：
1996-01-01
期刊：
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY
影响因子：
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作者：
Temonen, M;Mustonen, J;Holthofer, H
通讯作者：
Holthofer, H
影响因子：
6.1
作者：
Mäkelä, S;Hurme, M;Pasternack, A
通讯作者：
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