Escherichia coli and community-acquired gastroenteritis, Melbourne, Australia.
Escherichia coli and community-acquired gastroenteritis, Melbourne, Australia.
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DOI：
10.3201/eid1010.031086
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发表时间：
2004-10
影响因子：
11.8
通讯作者：
Hellard ME
中科院分区：
文献类型：
--
作者：
Robins-Browne RM;Bordun AM;Tauschek M;Bennett-Wood VR;Russell J;Oppedisano F;Lister NA;Bettelheim KA;Fairley CK;Sinclair MI;Hellard ME
肠致病性E.大肠杆菌是墨尔本肠胃炎的主要原因。作为确定水过滤对澳大利亚墨尔本社区获得性胃肠炎发病率的影响的研究的一部分，我们检查了胃肠炎患者和无症状人群的粪便样本中的大肠埃希菌菌株。肠致病性E.大肠杆菌（EPEC）是最常见的病原体的所有细菌，病毒和寄生虫剂的胃肠炎患者。此外，非典型EPEC在胃肠炎患者中（89/696 [12.8%]）比无症状患者（11/489 [2.3%]，p < 0.0001）更常见。22个随机分离的非典型EPEC的特点进一步表现出显着的异质性，血清型，遗传亚型，并携带毒力相关的决定因素。除了表面蛋白，内膜，没有毒力决定因素或表型均匀存在于非典型EPEC菌株。这项研究表明，非典型EPEC是墨尔本胃肠炎的一个重要原因。
Atypical strains of enteropathogenic E. coli are a leading cause of gastroenteritis in Melbourne. As part of a study to determine the effects of water filtration on the incidence of community-acquired gastroenteritis in Melbourne, Australia, we examined fecal samples from patients with gastroenteritis and asymptomatic persons for diarrheagenic strains of Escherichia coli. Atypical strains of enteropathogenic E. coli (EPEC) were the most frequently identified pathogens of all bacterial, viral, and parasitic agents in patients with gastroenteritis. Moreover, atypical EPEC were more common in patients with gastroenteritis (89 [12.8%] of 696) than in asymptomatic persons (11 [2.3%] of 489, p < 0.0001). Twenty-two random isolates of atypical EPEC that were characterized further showed marked heterogeneity in terms of serotype, genetic subtype, and carriage of virulence-associated determinants. Apart from the surface protein, intimin, no virulence determinant or phenotype was uniformly present in atypical EPEC strains. This study shows that atypical EPEC are an important cause of gastroenteritis in Melbourne.
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DOI：
10.1046/j.1440-1746.2000.02089.x
发表时间：
2000-03-01
影响因子：
4.1
作者：
Hellard, ME;Sinclair, MI;Fairley, CK
通讯作者：
Fairley, CK
影响因子：
64.8
作者：
Perna, NT;Plunkett, G;Blattner, FR
通讯作者：
Blattner, FR
影响因子：
10.4
作者：
Hellard, ME;Sinclair, MI;Fairley, CK
通讯作者：
Fairley, CK
影响因子：
3.1
作者：
Scaletsky, ICA;Pedroso, MZ;Fagundes-Neto, U
通讯作者：
Fagundes-Neto, U
影响因子：
9.4
作者：
BETTELHEIM, KA;THOMPSON, CJ
通讯作者：
THOMPSON, CJ