Learning from regeneration research organisms: The circuitous road to scar free wound healing.
Learning from regeneration research organisms: The circuitous road to scar free wound healing.
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DOI：
10.1016/j.ydbio.2017.09.025
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发表时间：
2018-01-15
影响因子：
2.7
通讯作者：
Echeverri K
中科院分区：
文献类型：
--
作者：
Erickson JR;Echeverri K
皮肤是人体最大的器官，起着多种重要作用，从调节温度，预防感染到最终定义我们的身体。它是一个高度动态的器官，在整个生命过程中不断替换最外层的细胞。然而，当面临重大损伤时，人类皮肤不能将显著损伤恢复到其原始功能，而是形成修复性疤痕。与此相反，许多其他物种具有再生全层皮肤而不形成疤痕组织的独特能力。在这里，我们回顾了该领域的最新进展，揭示了再生物种的皮肤细胞如何对损伤作出反应，以防止疤痕形成与疤痕形成人类。
The skin is the largest organ in the body and plays multiple essential roles ranging from regulating temperature, preventing infection and ultimately defining who we are physically. It is a highly dynamic organ that constantly replaces the outermost cells throughout life. However, when faced with a major injury, human skin cannot restore a significant lesion to its original functionality, instead a reparative scar is formed. In contrast to this, many other species have the unique ability to regenerate full thickness skin without formation of scar tissue. Here we review recent advances in the field that shed light on how the skin cells in regenerative species react to injury to prevent scar formation versus scar forming humans.
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影响因子：
2.4
作者：
BRUCEALLEN, LJ;GERACI, JR
通讯作者：
GERACI, JR
影响因子：
1.5
作者：
Bertolotti, Evelina;Malagoli, Davide;Franchini, Antonella
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Franchini, Antonella
影响因子：
6.5
作者：
Bin, Bum-Ho;Kim, Dae-Kyum;Cho, Eun-Gyung
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Cho, Eun-Gyung
影响因子：
4.4
作者：
Berberich, C;Ramírez-Pineda, JR;Moll, H
通讯作者：
Moll, H
影响因子：
11.8
作者：
Beck, CW;Christen, B;Slack, JMW
通讯作者：
Slack, JMW