The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients.
The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients.
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中国患者 HLA-DQB1、-DQA1 和 -DPB1 等位基因与抗肾小球基底膜 (GBM) 疾病的关联。
DOI：
10.1186/1471-2369-12-21
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发表时间：
2011-05-13
期刊：
影响因子：
2.3
通讯作者：
Zhao MH
中科院分区：
文献类型：
--
作者：
Luo H;Chen M;Cui Z;Yang R;Xu PC;Zhou XJ;Zhao MH
人类白细胞抗原（HLA）等位基因与许多自身免疫性疾病相关，包括抗肾小球基底膜（GBM）疾病。在我们以前的研究中，已经证实HLA-DRB 1 *1501与中国人抗GBM疾病密切相关。然而，抗GBM疾病与其他HLA II类基因，包括HLA-DQB 1，-DQA 1，-DPB 1等位基因的关联在亚洲人，特别是中国人中很少被研究。本研究进一步分析了抗GBM病与HLA-DQB 1、-DQA 1和-DPB 1基因的相关性。除此之外，我们还试图定位抗GBM疾病的潜在危险氨基酸残基。本研究包括44例中国抗GBM疾病患者和200例健康对照。收集并分析患者的临床和病理资料。使用SeCoreTM测序试剂盒通过外显子2的双向测序进行HLA-DQB 1、-DQA 1和-DPB 1等位基因的分型。与正常对照组相比，抗GBM疾病患者HLA-DPB 1 *0401的患病率显著降低（3/88 vs. 74/400，p = 4.4 × 10-4，pc = 0.039）。与正常对照组相比，抗GBM患者中DRB 1 *1501的存在和DPB 1 *0401的缺失的组合显著突出（p = 2.0 × 10-12，pc = 1.7 × 10-10）。HLA-DPB 1 *0401可能是中国人抗GBM病的保护性等位基因。DRB 1 *1501的联合存在和DPB 1 *0401的缺失可能比HLA-DRB 1 *1501单独存在具有更高的抗GBM疾病的风险。
Human leukocyte antigen (HLA) alleles are associated with many autoimmune diseases, including anti-glomerular basement membrane (GBM) disease. In our previous study, it was demonstrated that HLA-DRB1*1501 was strongly associated with anti-GBM disease in Chinese. However, the association of anti-GBM disease and other HLA class II genes, including HLA-DQB1, -DQA1,-DPB1 alleles, has rarely been investigated in Asian, especially Chinese patients. The present study further analyzed the association between anti-GBM disease and HLA-DQB1, -DQA1, and -DPB1 genes. Apart from this, we tried to locate the potential risk amino acid residues of anti-GBM disease. This study included 44 Chinese patients with anti-GBM disease and 200 healthy controls. The clinical and pathological data of the patients were collected and analyzed. Typing of HLA-DQB1, -DQA1 and -DPB1 alleles were performed by bi-directional sequencing of exon 2 using the SeCoreTM Sequencing Kits. Compared with normal controls, the prevalence of HLA-DPB1*0401 was significantly lower in patients with anti-GBM disease (3/88 vs. 74/400, p = 4.4 × 10-4, pc = 0.039). Comparing with normal controls, the combination of presence of DRB1*1501 and absence of DPB1*0401 was significantly prominent among anti-GBM patients (p = 2.0 × 10-12, pc = 1.7 × 10-10). HLA-DPB1*0401 might be a protective allele to anti-GBM disease in Chinese patients. The combined presence of DRB1*1501 and absence of DPB1*0401 might have an even higher risk to anti-GBM disease than HLA-DRB1*1501 alone.
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影响因子：
19.6
作者：
HUEY, B;MCCORMICK, K;WILSON, CB
通讯作者：
WILSON, CB
HLA-DRB1等位基因对中国抗GBM疾病易感性的作用。
影响因子：
8.6
作者：
Yang, Rui;Cui, Zhao;Zhao, Ming-Hui
通讯作者：
Zhao, Ming-Hui
影响因子：
82.9
作者：
Kotb, M;Norrby-Teglund, A;Low, DE
通讯作者：
Low, DE
影响因子：
4.4
作者：
Phelps, RG;Jones, V;Rees, AJ
通讯作者：
Rees, AJ
DOI：
10.1073/pnas.0707731105
发表时间：
2007-12-26
影响因子：
11.1
作者：
DeLuca, G. C.;Ramagopalan, S. V.;Ebers, G. C.
通讯作者：
Ebers, G. C.