CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?
CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?
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DOI：
10.3389/fimmu.2018.02316
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发表时间：
2018
影响因子：
7.3
通讯作者：
Brouard S
中科院分区：
文献类型：
--
作者：
Brosseau C;Colas L;Magnan A;Brouard S
CD 9属于四跨膜蛋白超家族。根据细胞类型和相关分子，CD 9具有多种生物活性，如细胞粘附、运动、转移、生长、信号转导、分化和精卵融合。本文综述了造血细胞表达CD 9及其在调节炎症细胞过程中的作用。CD 9在许多疾病中功能非常重要，并且参与疾病的调节或介导。CD 9在各种疾病中的作用，如病毒和细菌感染，癌症和慢性肺移植功能障碍，进行了讨论。这篇综述还关注其作为疾病生物标志物的兴趣。事实上，CD 9主要被认为是一种特异性外泌体标志物，然而，它的表达现在被认为是单核细胞和巨噬细胞的抗炎标志物。它也被描述为小鼠IL-10感受态布雷格细胞和IL-10分泌型CD 9 + B细胞的标志物，与肺移植患者中更好的同种异体移植物结局相关，并被鉴定为长期存活的新预测生物标志物。在癌症领域，CD 9被鉴定为有利的预后标志物或取决于癌症类型的转移潜力的预测因子。最后，这篇综述讨论了靶向CD 9作为治疗工具的策略。由于CD 9可以根据情况、环境和病理学而具有相反的作用，因此调节CD 9表达或阻断其作用似乎是一种新的有前途的治疗策略。
CD9 belongs to the tetraspanin superfamily. Depending on the cell type and associated molecules, CD9 has a wide variety of biological activities such as cell adhesion, motility, metastasis, growth, signal transduction, differentiation, and sperm–egg fusion. This review focuses on CD9 expression by hematopoietic cells and its role in modulating cellular processes involved in the regulation of inflammation. CD9 is functionally very important in many diseases and is involved either in the regulation or in the mediation of the disease. The role of CD9 in various diseases, such as viral and bacterial infections, cancer and chronic lung allograft dysfunction, is discussed. This review focuses also on its interest as a biomarker in diseases. Indeed CD9 is primarily known as a specific exosome marker however, its expression is now recognized as an anti-inflammatory marker of monocytes and macrophages. It was also described as a marker of murine IL-10-competent Breg cells and IL-10-secreting CD9+ B cells were associated with better allograft outcome in lung transplant patients, and identified as a new predictive biomarker of long-term survival. In the field of cancer, CD9 was both identified as a favorable prognostic marker or as a predictor of metastatic potential depending on cancer types. Finally, this review discusses strategies to target CD9 as a therapeutic tool. Because CD9 can have opposite effects depending on the situation, the environment and the pathology, modulating CD9 expression or blocking its effects seem to be a new promising therapeutic strategy.
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DOI：
10.4049/jimmunol.0803052
发表时间：
2009-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Blair PA;Chavez-Rueda KA;Evans JG;Shlomchik MJ;Eddaoudi A;Isenberg DA;Ehrenstein MR;Mauri C
通讯作者：
Mauri C
影响因子：
3.3
作者：
Wu, Jing Qin;Dyer, Wayne B.;Chrisp, Jeremy;Belov, Larissa;Wang, Bin;Saksena, Nitin K.
通讯作者：
Saksena, Nitin K.
影响因子：
4.2
作者：
Amatya VJ;Takeshima Y;Aoe K;Fujimoto N;Okamoto T;Yamada T;Kishimoto T;Morimoto C;Inai K
通讯作者：
Inai K
影响因子：
12.4
作者：
Braza, F.;Chesne, J.;Brouard, S.
通讯作者：
Brouard, S.
影响因子：
1.5
作者：
Chung, Byung Ha;Kim, Kyoung Woon;Yang, Chul Woo
通讯作者：
Yang, Chul Woo