Prospective assessment of adjunctive ultrasound-guided diffuse optical tomography in women undergoing breast biopsy: Impact on BI-RADS assessments.
Prospective assessment of adjunctive ultrasound-guided diffuse optical tomography in women undergoing breast biopsy: Impact on BI-RADS assessments.
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DOI：
10.1016/j.ejrad.2021.110029
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发表时间：
2021-12
影响因子：
3.3
通讯作者：
Zhu, Quing
中科院分区：
文献类型：
--
作者：
Poplack, Steven P.;Young, Catherine A.;Hagemann, Ian S.;Luo, Jingqin;Herman, Cheryl R.;Wiele, Kimberly;Li, Shuying;Zeng, Yifeng;Covington, Matthew F.;Zhu, Quing
评估连续超声引导扩散光学断层扫描（US引导DOT）对接受US引导乳腺活检的女性BI-RADS评估的影响。这项前瞻性研究招募了2019年3月5日至2020年3月19日期间转诊接受US引导下乳腺活检的女性。参与者在活检前立即接受了US引导的DOT。超声引导DOT采集生成平均最大总血红蛋白（HbT）空间图和定量HbT值。四名对组织病理学不知情的放射科医师评估常规成像（CI）以分配CI BI-RADS评估，然后在分配CI&DOT BI-RADS评估时整合DOT信息。使用ANOVA检验和Tukey检验比较良性和恶性病变之间的HbT。将良性活检制成表格，将BI-RADS ≥ 4A视为阳性。评估了读者同意度。在61名女性（平均年龄48岁）中，活检显示15例（24.6%）恶性病变和46例（75.4%）良性病变。良性病变的平均HbT为55.3 ± 22.6 μM，而癌症为85.4 ± 15.6 μM（p <0.001）。HbT阈值为78.5 μM时，诊断恶性肿瘤的敏感性为80%（12/15），特异性为89%（41/46）。在读片者和患者中，分配了197对CI BI-RADS和CI&DOT BI-RADS评估。辅助超声引导DOT实现了良性病变可疑（CI BI-RADS ≥ 4A）评估的23.5%（31/132）净减少（34次正确降级和3次不正确升级）。38.3%（31/81）的4A评估被适当降级。没有癌症被降级为不可采取行动的评估。阅片员间一致性分析表明CI BI-RADS的kappa = 0.48-0.53，CI&DOT BI-RADS的kappa = 0.28-0.44。整合超声引导下DOT信息使良性病变的可疑BI-RADS评估减少了23.5%。更大的研究是必要的，注意提高读者的一致性。
To assess the impact of adjunctive ultrasound guided diffuse optical tomography (US-guided DOT) on BI-RADS assessment in women undergoing US-guided breast biopsy. This prospective study enrolled women referred for US-guided breast biopsy between 3/5/2019 and 3/19/2020. Participants underwent US-guided DOT immediately before biopsy. The US-guided DOT acquisition generated average maximum total hemoglobin (HbT) spatial maps and quantitative HbT values. Four radiologists blinded to histopathology assessed conventional imaging (CI) to assign a CI BI-RADS assessment and then integrated DOT information in assigning a CI&DOT BI-RADS assessment. HbT was compared between benign and malignant lesions using an ANOVA test and Tukey’s test. Benign biopsies were tabulated, deeming BI-RADS ≥ 4A as positive. Reader agreement was assessed. Among 61 included women (mean age 48 years), biopsy demonstrated 15 (24.6%) malignant and 46 (75.4%) benign lesions. Mean HbT was 55.3 ± 22.6 μM in benign lesions versus 85.4 ± 15.6 μM in cancers (p < .001). HbT threshold of 78.5 μM achieved sensitivity 80% (12/15) and specificity 89% (41/46) for malignancy. Across readers and patients, 197 pairs of CI BI-RADS and CI&DOT BI-RADS assessments were assigned. Adjunctive US-guided DOT achieved a net decrease in 23.5% (31/132) of suspicious (CI BI-RADS ≥ 4A) assessments of benign lesions (34 correct downgrades and 3 incorrect upgrades). 38.3% (31/81) of 4A assessments were appropriately downgraded. No cancer was downgraded to a non-actionable assessment. Interreader agreement analysis demonstrated kappa = 0.48–0.53 for CI BI-RADS and kappa = 0.28–0.44 for CI&DOT BI-RADS. Integration of US-guided DOT information achieved a 23.5% reduction in suspicious BI-RADS assessments for benign lesions. Larger studies are warranted, with attention to improved reader agreement.
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影响因子：
19.7
作者：
Zhu, Quing;Hegde, Poornima U.;Tannenbaum, Susan H.
通讯作者：
Tannenbaum, Susan H.
影响因子：
19.7
作者：
Poplack, Steven P.;Tosteson, Tor D.;Paulsen, Keith D.
通讯作者：
Paulsen, Keith D.
影响因子：
7.4
作者：
Feng, Jinchao;Xu, Junqing;Paulsen, Keith D.
通讯作者：
Paulsen, Keith D.
DOI：
10.1158/1078-0432.ccr-14-2546
发表时间：
2015-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Mastanduno MA;Xu J;El-Ghussein F;Jiang S;Yin H;Zhao Y;Wang K;Ren F;Gui J;Pogue BW;Paulsen KD
通讯作者：
Paulsen KD
影响因子：
19.7
作者：
Neuschler, Erin I.;Butler, Reni;Dogan, Basak E.
通讯作者：
Dogan, Basak E.