Risk factors for subclinical atherosclerosis in diabetic and obese children.
Risk factors for subclinical atherosclerosis in diabetic and obese children.
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DOI：
10.7150/ijms.5181
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发表时间：
2013
影响因子：
3.6
通讯作者：
Cavallo L
中科院分区：
文献类型：
--
作者：
Faienza MF;Acquafredda A;Tesse R;Luce V;Ventura A;Maggialetti N;Monteduro M;Giordano P;Cavallo L
背景颈动脉内膜中层厚度（cIMT）增加被认为是早发性动脉粥样硬化的标志物，似乎可以预测肥胖和糖尿病受试者的心血管事件。我们的目的是评估动脉粥样硬化的早期体征，并调查受1型糖尿病（T1 DM）或肥胖影响的儿童和青少年的易感因素，并与健康对照组进行比较。方法.在71例入组受试者（平均年龄12.8 ± 2.3岁）中，26例患有T1 DM，24例肥胖，而21例年龄和性别匹配的受试者作为对照。使用标准化方法测量cIMT。评估血清葡萄糖、胰岛素、胆固醇、甘油三酯和C反应蛋白水平。在肥胖受试者中进行口服葡萄糖耐量试验（OGTT）。结果糖尿病和肥胖个体显示出比健康对照更高的cIMT平均值（p<0.005）。在T1 DM个体中，三个检查节段的cIMT与空腹血糖水平呈正相关，与胰岛素单位/kg/天呈负相关。肥胖组基础胰岛素水平和糖负荷后胰岛素水平与颈总动脉、颈内动脉和颈外动脉cIMT呈正相关（P<0.03）。高密度胆固醇水平代表了后一组研究人群中cIMT的保护因素。结论.我们的研究结果表明，cIMT与肥胖患者的高胰岛素水平（胰岛素抵抗的标志）和T1 DM受试者的高空腹血糖水平（相对胰岛素缺乏的标志）相关，证实需要减少高胰岛素血症和监测这些受试者的血糖水平，以预防动脉粥样硬化。
Background. Increased carotid intima-media thickness (cIMT) is considered a marker of early-onset atherosclerosis and it seems to predict cardiovascular events both in obese and diabetic subjects. We aimed to evaluate early signs of atherosclerosis and investigate for predisposing factors in children and adolescents affected by type 1 diabetes (T1DM) or obesity, comparing them with healthy controls. Methods. Out of 71 enrolled subjects (mean age 12.8 ± 2.3 years), 26 had T1DM and 24 were obese, while 21 age- and sex-matched subjects acted as controls. cIMT was measured using standardized methods. Serum glucose, insulin, cholesterol, triglycerides and C-reactive protein levels were evaluated. An oral glucose tolerance test (OGTT) was performed in obese subjects. Results. Diabetic and obese individuals showed higher cIMT mean values than healthy controls (p<0.005). cIMT of the three examined segments correlated positively with fasting glucose levels and negatively with units of insulin/kg/day administered in T1DM individuals. A positive correlation between insulin levels (basal and after oral glucose load) and cIMT of common, internal and external carotid artery was found in obese subjects (p<0.03). High density cholesterol levels represented a protective factor for cIMT in this latter group of the study population. Conclusions. Our findings show that cIMT correlates with high insulin levels (a sign of insulin resistance) in obese patients and with high fasting glucose levels (a sign of relative insulin deficiency) in T1DM subjects, confirming the need of reducing hyperinsulinism and monitoring blood glucose levels in these subjects to prevent atherosclerosis.
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影响因子：
8.3
作者：
Lorenz, MW;von Kegler, S;Sitzer, M
通讯作者：
Sitzer, M
影响因子：
7.7
作者：
Järvisalo, MJ;Putto-Laurila, A;Raitakari, OT
通讯作者：
Raitakari, OT
影响因子：
8.2
作者：
Margeirsdottir, H. D.;Larsen, J. R.;Dahl-Jorgensen, K.
通讯作者：
Dahl-Jorgensen, K.
影响因子：
16.2
作者：
Lee, Sun Hee;Kim, Jae Hyun;Shin, Choong Ho
通讯作者：
Shin, Choong Ho
影响因子：
5.1
作者：
Atabek, Mehmet Emre;Kurtoglu, Selim;Baykara, Murat
通讯作者：
Baykara, Murat