Microbiota that affect risk for shigellosis in children in low-income countries.
Microbiota that affect risk for shigellosis in children in low-income countries.
复制标题
DOI：
10.3201/eid2101.140795
复制
发表时间：
2015-02
影响因子：
11.8
通讯作者：
Stine OC
中科院分区：
文献类型：
--
作者：
Lindsay B;Oundo J;Hossain MA;Antonio M;Tamboura B;Walker AW;Paulson JN;Parkhill J;Omore R;Faruque AS;Das SK;Ikumapayi UN;Adeyemi M;Sanogo D;Saha D;Sow S;Farag TH;Nasrin D;Li S;Panchalingam S;Levine MM;Kotloff K;Magder LS;Hungerford L;Sommerfelt H;Pop M;Nataro JP;Stine OC
与志贺氏菌共感染和其他微生物改变腹泻的风险。胃肠道中的病原体存在于大量的微生物群体中。我们研究了病原体与肠道微生物群组成之间的关联，因为它们与志贺氏菌属/肠侵袭性大肠杆菌感染。我们分析了来自全球肠道多中心研究的3，035份粪便标本（1，735份非肠道和1，300份中度至重度肠道）中的9种肠道病原体。腹泻标本的肠道病原体数量较多（腹泻平均1.4，非腹泻平均0.95; p<0.0001）。轮状病毒与志贺菌呈负相关。在腹泻病例中（比值比0.31，95% CI 0.17-0.55），对中度至重度腹泻有较大的联合效应（比值比29，95% CI 3.8-220）。16 S rRNA基因测序鉴定的4个乳杆菌类群中，病原菌与疾病的关联性降低，这与乳杆菌属的可能性相一致。对志贺氏菌引起的腹泻有保护作用。肠道菌群的细菌多样性与腹泻状态相关，而不是高水平的志贺氏菌。ipaH基因。
Co-infection with Shigella spp. and other microbes modifies diarrhea risk. Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17–0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8–220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.–induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.
登录
查看更多内容
影响因子：
--
作者：
Srikanth CV;McCormick BA
通讯作者：
McCormick BA
影响因子：
168.9
作者：
Lozano, Rafael;Naghavi, Mohsen;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
2.3
作者：
Hansson, Lisbeth;Khamis, Harry J.
通讯作者：
Khamis, Harry J.
影响因子：
13.6
作者：
Andersson, T;Alfredsson, L;Ahlbom, A
通讯作者：
Ahlbom, A
影响因子：
168.9
作者：
Kotloff, Karen L.;Nataro, James P.;Levine, Myron M.
通讯作者：
Levine, Myron M.