Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene
Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene
复制标题
通过 c-bas/has 人类原癌基因内的替代点突变获得转化特性
作者：
Y. Yuasa;S. Srivastava;C. Y. Dunn;J. Rhim;E. Reddy;S. Aaronson
人肺癌细胞系 Hs242 的转化基因已以生物活性形式克隆，并被鉴定为 c-bas/has（也称为 c-Ha-ras）。负责 Hs242 癌基因转化活性的遗传损伤已定位于第二个外显子中的点突变，导致亮氨酸取代谷氨酰胺作为预测蛋白质的氨基酸 61。在第一个外显子（c-bas/has 区域）中没有观察到任何变化，其中点突变负责 T24 和 EJ 膀胱癌癌基因的激活。
The transforming gene of a human lung carcinoma-derived cell line, Hs242, has been cloned in biologically active form, and identified as c-bas/has (otherwise known as c-Ha-ras). The genetic lesion responsible for the transforming activity of the Hs242 oncogene has been localized to a point mutation in the second exon which results in the substitution of leucine for glutamine as amino acid 61 of the predicted protein. No changes were observed in the first exon, the region of c-bas/has in which a point mutation is responsible for activation of the T24 and EJ bladder carcinoma oncogenes.
禽肉瘤病毒和猫肉瘤病毒的转化序列之间存在同源性。
DOI：
10.1073/pnas.77.11.6536
发表时间：
1980
影响因子：
11.1
作者：
Shibuya,M;Hanafusa,T;Hanafusa,H;Stephenson,JR
通讯作者：
Stephenson,JR
影响因子：
56.9
作者：
TSUCHIDA, N;RYDER, T;OHTSUBO, E
通讯作者：
OHTSUBO, E