Long-term urban particulate air pollution, traffic noise, and arterial blood pressure.
Long-term urban particulate air pollution, traffic noise, and arterial blood pressure.
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DOI：
10.1289/ehp.1103564
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发表时间：
2011-12
影响因子：
10.4
通讯作者：
Heinz Nixdorf Recall Study Investigative Group
中科院分区：
文献类型：
--
作者：
Fuks K;Moebus S;Hertel S;Viehmann A;Nonnemacher M;Dragano N;Möhlenkamp S;Jakobs H;Kessler C;Erbel R;Hoffmann B;Heinz Nixdorf Recall Study Investigative Group
背景：最近的研究表明，短期接触细颗粒物 (PM) 与血压 (BP) 短暂升高有关，但尚不清楚长期接触细颗粒物 (PM) 是否对动脉血压和高血压有影响。目的：我们研究了住宅长期 PM 暴露与动脉血压和高血压的横断面关联，同时考虑了 PM 的短期变化和长期道路交通噪声暴露。方法：我们使用来自 Heinz Nixdorf Recall Study（一项德国基于人群的前瞻性队列）的 4,291 名 45-75 岁参与者的基线数据（2000-2003 年）。使用扩散和化学传输模型评估空气动力学直径≤ 2.5 μm (PM2.5) 和≤ 10 μm (PM10) 的城市背景暴露。我们使用广义累加模型，对短期 PM、气象、交通邻近度和个人风险因素进行调整。结果：PM2.5 (2.4 μg/m3) 四分位数增加与平均收缩压和舒张压估计分别增加 1.4 mmHg [95% 置信区间 (CI)：0.5, 2.3] 和 0.9 mmHg (95% CI: 0.4, 1.4) 相关。观察到的关系与长期暴露于道路交通噪音无关，并且在包含许多潜在混杂因素的情况下保持稳健。靠近交通繁忙和交通噪音暴露的住宅区显示出血压升高和高血压患病率升高的趋势。结论：我们在基于人群的样本中发现，长期接触 PM 与动脉血压升高存在关联。这一发现支持了我们的假设，即长期接触 PM 可能会促进动脉粥样硬化，其中空气污染引起的血压升高是一种可能的生物途径。
Background: Recent studies have shown an association of short-term exposure to fine particulate matter (PM) with transient increases in blood pressure (BP), but it is unclear whether long-term exposure has an effect on arterial BP and hypertension. Objectives: We investigated the cross-sectional association of residential long-term PM exposure with arterial BP and hypertension, taking short-term variations of PM and long-term road traffic noise exposure into account. Methods: We used baseline data (2000–2003) on 4,291 participants, 45–75 years of age, from the Heinz Nixdorf Recall Study, a population-based prospective cohort in Germany. Urban background exposure to PM with aerodynamic diameter ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) was assessed with a dispersion and chemistry transport model. We used generalized additive models, adjusting for short-term PM, meteorology, traffic proximity, and individual risk factors. Results: An interquartile increase in PM2.5 (2.4 μg/m3) was associated with estimated increases in mean systolic and diastolic BP of 1.4 mmHg [95% confidence interval (CI): 0.5, 2.3] and 0.9 mmHg (95% CI: 0.4, 1.4), respectively. The observed relationship was independent of long-term exposure to road traffic noise and robust to the inclusion of many potential confounders. Residential proximity to high traffic and traffic noise exposure showed a tendency toward higher BP and an elevated prevalence of hypertension. Conclusions: We found an association of long-term exposure to PM with increased arterial BP in a population-based sample. This finding supports our hypothesis that long-term PM exposure may promote atherosclerosis, with air-pollution–induced increases in BP being one possible biological pathway.
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影响因子：
4.9
作者：
Brook, Robert D.;Bard, Robert L.;Williams, Ron
通讯作者：
Williams, Ron
DOI：
10.1097/ede.0b013e31819644cc
发表时间：
2009-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Allen RW;Criqui MH;Diez Roux AV;Allison M;Shea S;Detrano R;Sheppard L;Wong ND;Stukovsky KH;Kaufman JD
通讯作者：
Kaufman JD
影响因子：
4.9
作者：
Bluhm, Gosta Leon;Berglind, Niklas;Rosenlund, Mats
通讯作者：
Rosenlund, Mats
影响因子：
37.8
作者：
Hoffmann, B.;Moebus, S.;Joeckel, K.-H.
通讯作者：
Joeckel, K.-H.
影响因子：
6
作者：
Bodin, Theo;Albin, Maria;Bjork, Jonas
通讯作者：
Bjork, Jonas