New Parvovirus Associated with Serum Hepatitis in Horses after Inoculation of Common Biological Product.
New Parvovirus Associated with Serum Hepatitis in Horses after Inoculation of Common Biological Product.
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接种普通生物产物后，新的细小病毒与马匹中的血清肝炎有关。
DOI：
10.3201/eid2402.171031
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发表时间：
2018-03
影响因子：
11.8
通讯作者：
Kapoor A
中科院分区：
文献类型：
--
作者：
Divers TJ;Tennant BC;Kumar A;McDonough S;Cullen J;Bhuva N;Jain K;Chauhan LS;Scheel TKH;Lipkin WI;Laverack M;Trivedi S;Srinivasa S;Beard L;Rice CM;Burbelo PD;Renshaw RW;Dubovi E;Kapoor A
马血清肝炎（即，泰勒病（Theiler's disease）是一种病因不明的严重且经常危及生命的疾病，影响马匹。美国内布拉斯加州的一匹患有血清肝炎的马在接受马源性破伤风抗毒素治疗后65天死亡。我们在死马的血清和肝脏以及给药的抗毒素中鉴定出一种未知的细小病毒。马细小病毒肝炎（EquineParvovirus-Hepatitis，EqPV-H）与Copiparvovirus属的系统发育相关病毒具有<50%的同源性。接下来，我们使用被EqPV-H污染的破伤风抗毒素实验性感染2匹马。出现病毒血症，马发生血清转化，并出现急性肝炎，经临床、生化和组织病理学检测证实。我们还确定EqPV-H是一种地方性感染，因为在100匹临床正常成年马的队列中，13匹为病毒血症，15匹为血清阳性。我们鉴定了一种与马血清性肝炎相关的新病毒，并证实了其致病性和通过污染生物制品的传播性。
Equine serum hepatitis (i.e., Theiler’s disease) is a serious and often life-threatening disease of unknown etiology that affects horses. A horse in Nebraska, USA, with serum hepatitis died 65 days after treatment with equine-origin tetanus antitoxin. We identified an unknown parvovirus in serum and liver of the dead horse and in the administered antitoxin. The equine parvovirus-hepatitis (EqPV-H) shares <50% protein identity with its phylogenetic relatives of the genus Copiparvovirus. Next, we experimentally infected 2 horses using a tetanus antitoxin contaminated with EqPV-H. Viremia developed, the horses seroconverted, and acute hepatitis developed that was confirmed by clinical, biochemical, and histopathologic testing. We also determined that EqPV-H is an endemic infection because, in a cohort of 100 clinically normal adult horses, 13 were viremic and 15 were seropositive. We identified a new virus associated with equine serum hepatitis and confirmed its pathogenicity and transmissibility through contaminated biological products.
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影响因子：
1.7
作者：
Burbelo, Peter D.;Ragheb, Jack A.;Kapoor, Amit;Zhang, Yanjin
通讯作者：
Zhang, Yanjin
影响因子：
13.5
作者：
Ramsay, Joshua D.;Evanoff, Ryan;Mealey, Robert H.
通讯作者：
Mealey, Robert H.
影响因子：
3.8
作者：
Lyons, Sinead;Kapoor, Amit;Simmonds, Peter
通讯作者：
Simmonds, Peter
影响因子：
6.4
作者：
Kapoor A;Kumar A;Simmonds P;Bhuva N;Singh Chauhan L;Lee B;Sall AA;Jin Z;Morse SS;Shaz B;Burbelo PD;Lipkin WI
通讯作者：
Lipkin WI
DOI：
10.1073/pnas.1219217110
发表时间：
2013-04-09
影响因子：
11.1
作者：
Chandriani, Sanjay;Skewes-Cox, Peter;Kistler, Amy L.
通讯作者：
Kistler, Amy L.