Associations between cohort derived dementia and COVID-19 serological diagnosis among older Black adults in rural South Africa.
Associations between cohort derived dementia and COVID-19 serological diagnosis among older Black adults in rural South Africa.
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DOI：
10.3389/fpubh.2023.1304572
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发表时间：
2023
影响因子：
5.2
通讯作者：
Berkman, Lisa F.
中科院分区：
文献类型：
--
作者：
Harriman, Nigel Walsh;Bassil, Darina T.;Farrell, Meagan T.;Du Toit, Jacques;Casas, F. Xavier Gomez-Olive;Tollman, Stephen M.;Berkman, Lisa F.
这项研究调查了队列衍生痴呆症和血清学证实的SARS-CoV-2感染之间的关系，这是一种在低收入和中等收入国家未充分研究的现象。在南非农村社区环境中研究这种关系提供了适用于更广泛的医疗保健背景的见解。数据收集自姆普马兰加省的南非黑人，他们参加了非洲的健康与老龄化：南非INDEPTH社区的纵向研究。使用基于共识的痴呆诊断预测模型开发了队列衍生的痴呆。多项逻辑回归模型估计了2018年预测的痴呆概率与2021年SARS-CoV-2感染风险之间的关联，控制了人口统计学，社会经济状况和合并症。52%的受试者有血清学证实的SARS-CoV-2感染。在完全调整的模型中，队列衍生的痴呆与COVID-19血清学诊断风险的两倍以上显着相关（RRR = 2.12，p = 0.045）。对于因症状而认知功能受损的个人来说，遵守COVID-19预防建议可能很困难。研究结果可以为基于社区的公共卫生举措提供信息，以减少南非快速老龄化人口中的COVID-19传播。
This study investigates the association between cohort derived dementia and serologically confirmed SARS-CoV-2 infection, an underexplored phenomena in low-and middle-income countries. Examining this relationship in a rural South African community setting offers insights applicable to broader healthcare contexts. Data were collected from Black South Africans in the Mpumalanga province who participated in the Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa. Cohort derived dementia was developed using a predictive model for consensus-based dementia diagnosis. Multinomial logistic regression models estimated the association between predicted dementia probability in 2018 and SARS-CoV-2 infection risk in 2021, controlling for demographics, socioeconomic status, and comorbidities. Fifty-two percent of the tested participants had serologically confirmed SARS-CoV-2 infections. In the fully adjusted model, cohort derived dementia was significantly associated with over twice the risk of serological diagnosis of COVID-19 (RRR = 2.12, p = 0.045). Complying with COVID-19 prevention recommendations may be difficult for individuals with impaired cognitive functioning due to their symptoms. Results can inform community-based public health initiatives to reduce COVID-19 transmission among South Africa’s rapidly aging population.
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影响因子：
6.3
作者：
Bayer, Thomas A.;DeVone, Frank;McConeghy, Kevin W.;Halladay, Christopher W.;Quach, Lien;Rajan, Ashna;Elhamamsy, Salaheldin;Cadieux, Marilyne;Singh, Mriganka;Sachar, Moniyka;Nanda, Aman;Gravenstein, Stefan;Rudolph, James L.
通讯作者：
Rudolph, James L.
DOI：
10.1177/14713012221117905
发表时间：
2022-10
影响因子：
2.4
作者：
Mahomed, Aqeela;Pretorius, Chrisma
通讯作者：
Pretorius, Chrisma
影响因子：
6.7
作者：
Al Hasan, Syed Mahfuz;Saulam, Jennifer;Mikami, Fumiaki;Kanda, Kanae;Yokoi, Hideto;Hirao, Tomohiro
通讯作者：
Hirao, Tomohiro
影响因子：
7
作者：
Gyasi RM
通讯作者：
Gyasi RM
影响因子：
7.7
作者：
Kahn K;Collinson MA;Gómez-Olivé FX;Mokoena O;Twine R;Mee P;Afolabi SA;Clark BD;Kabudula CW;Khosa A;Khoza S;Shabangu MG;Silaule B;Tibane JB;Wagner RG;Garenne ML;Clark SJ;Tollman SM
通讯作者：
Tollman SM