Recent advances in the Suf Fe-S cluster biogenesis pathway: Beyond the Proteobacteria.
Recent advances in the Suf Fe-S cluster biogenesis pathway: Beyond the Proteobacteria.
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DOI：
10.1016/j.bbamcr.2014.11.001
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发表时间：
2015-06
影响因子：
5.1
通讯作者：
Outten, F. Wayne
中科院分区：
文献类型：
--
作者：
Outten, F. Wayne
Fe-S簇在所有生命领域的细胞功能中起着关键作用。因此，Fe-S簇生物发生系统存在于大多数生物体中。Suf（硫形成）系统是三种具有特征的Fe-S簇生物发生途径中最古老的，其中还包括Isc和Nif系统。许多关于Suf系统的最初工作发生在作为模式生物的革兰氏阴性变形杆菌中。这些早期的研究带来了丰富的关于Suf功能的生化、遗传和生理信息。从这些研究中，我们了解到SufB与SufC（在某些情况下是SufD）一起作为Fe-S支架起作用。suf和SufE共同动员硫进行簇组装，SufA将完整的Fe-S簇从SufB运输到靶载脂蛋白。然而，近年来对其他生物体中Suf系统的研究进展为Suf功能的研究开辟了新的途径和新的假设。这篇综述主要集中在Suf通路的最新发现以及这些新模型可能引领该领域的方向。
Fe-S clusters play critical roles in cellular function throughout all three kingdoms of life. Consequently, Fe-S cluster biogenesis systems are present in most organisms. The Suf (sulfur formation) system is the most ancient of the three characterized Fe-S cluster biogenesis pathways, which also include the Isc and Nif systems. Much of the first work on the Suf system took place in Gram-negative Proteobacteria used as model organisms. These early studies led to a wealth of biochemical, genetic, and physiological information on Suf function. From those studies we have learned that SufB functions as an Fe-S scaffold in conjunction with SufC (and in some cases SufD). SufS and SufE together mobilize sulfur for cluster assembly and SufA traffics the complete Fe-S cluster from SufB to target apo-proteins. However, recent progress on the Suf system in other organisms has opened up new avenues of research and new hypotheses about Suf function. This review focuses primarily on the most recent discoveries about the Suf pathway and where those new models may lead the field.
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