Air pollution and circulating biomarkers of oxidative stress.
Air pollution and circulating biomarkers of oxidative stress.
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DOI：
10.1007/s11869-010-0095-2
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发表时间：
2011-03-01
影响因子：
5.1
通讯作者：
Vaziri, Nosratola D.
中科院分区：
文献类型：
--
作者：
Delfino, Ralph J.;Staimer, Norbert;Vaziri, Nosratola D.
空气污染物暴露的化学成分诱导氧化应激和随后的炎症可能是部分负责心血管疾病的发病率和死亡率与空气中的颗粒物和燃烧相关的污染气体。然而，关于这一点的流行病学证据是有限的。一种可靠的评估方法是测量颗粒混合物的氧化潜力，因为空气污染对健康的总体影响可能涉及数百种相关化学物质。氧化电位可能取决于颗粒组成和粒度分布，特别是超细颗粒浓度，以及过渡金属和某些半挥发性和挥发性有机化学品。对于健康影响，测量血液中的全身性氧化应激是一种可行的方法，但是没有氧化应激的通用生物标志物，并且存在许多潜在的靶分子（脂质、蛋白质、DNA、一氧化氮等），这可能或多或少适合于特定的研究目标。与氧化应激的测量同时，重要的是测量内源性抗氧化酶的基因和/或蛋白质表达，因为它们可以改变氧化应激生物标志物和空气污染物之间的关系。相反，这些酶的表达和活性被氧化应激改变。这种相互作用可能会决定所观察到的空气污染物对全身炎症和血栓形成介质以及相关临床结果的影响。需要研究来评估氧化应激生物标志物的可靠性和有效性，评估氧化应激生物标志物和各种污染物测量（质量，化学成分和氧化电位）之间的关联差异，并评估抗氧化反应对这些关系的影响。
Chemical components of air pollutant exposures that induce oxidative stress and subsequent inflammation may be partly responsible for associations of cardiovascular morbidity and mortality with airborne particulate matter and combustion-related pollutant gasses. However, epidemiologic evidence regarding this is limited. An exposure-assessment approach is to measure the oxidative potential of particle mixtures because it is likely that hundreds of correlated chemicals are involved in overall effects of air pollution on health. Oxidative potential likely depends on particle composition and size distribution, especially ultrafine particle concentration, and on transition metals and certain semivolatile and volatile organic chemicals. For health effects, measuring systemic oxidative stress in the blood is one feasible approach, but there is no universal biomarker of oxidative stress and there are many potential target molecules (lipids, proteins, DNA, nitric oxide, etc.), which may be more or less suitable for specific study goals. Concurrent with the measurement of oxidative stress, it is important to measure gene and/or protein expression of endogenous antioxidant enzymes because they can modify relations between oxidative stress biomarkers and air pollutants. Conversely, the expression and activities of these enzymes are modified by oxidative stress. This interplay will likely determine the observed effects of air pollutants on systemic inflammatory and thrombotic mediators and related clinical outcomes. Studies are needed to assess the reliability and validity of oxidative stress biomarkers, evaluate differences in associations between oxidative stress biomarkers and various pollutant measurements (mass, chemical components, and oxidative potential), and evaluate impacts of antioxidant responses on these relations.
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DOI：
10.1164/rccm.200611-1627oc
发表时间：
2007-08-15
影响因子：
24.7
作者：
Chuang, Kai-Jen;Chan, Chang-Chuan;Tang, Chin-Sheng
通讯作者：
Tang, Chin-Sheng
影响因子：
3.8
作者：
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通讯作者：
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影响因子：
10
作者：
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DOI：
10.1165/ajrcmb.25.4.4515
发表时间：
2001-10-01
影响因子：
6.4
作者：
Bonvallot, V;Baeza-Squiban, A;Marano, F
通讯作者：
Marano, F
影响因子：
4.9
作者：
Alexeeff, S. E.;Litonjua, A. A.;Schwartz, J.
通讯作者：
Schwartz, J.