Biodistribution, toxicology, and radiation dosimetry of 5-HT1A-receptor agonist positron emission tomography ligand [11C]CUMI-101.
Biodistribution, toxicology, and radiation dosimetry of 5-HT1A-receptor agonist positron emission tomography ligand [11C]CUMI-101.
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DOI：
10.1177/1091581811419024
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发表时间：
2011-12
影响因子：
2.2
通讯作者：
Parsey RV
中科院分区：
文献类型：
--
作者：
Kumar DJ;Bai B;Ng HH;Mirsalis JC;Erlandsson K;Milak MS;Majo VJ;Prabhakaran J;Mann JJ;Parsey RV
Sprague Dawley rats (10/sex/group) were given a single iv dose of CUMI-101 to determine acute toxicity of CUMI-101 and radiation dosimetry estimations were conducted in baboons with [11C]CUMI-101. Intravenous administration of CUMI-101 did not produce overt biologically or toxicologically significant adverse effects except transient hypoactivity immediately post dose in the mid and high dose groups, which is not considered to be a dose limiting toxic effect. No adverse effects were observed in the low dose group. The no observed adverse effect level (NOAEL) is considered to be 44.05 µg/kg for a single iv dose administration in rats. The maximum tolerated dose (MTD) was estimated to be 881 µg/kg for a single iv dose administration. The Medical Internal Radiation Dose (MIRDOSE) estimates indicate the maximum, permissible single study dosage of [11C]CUMI-101 in human is 52 mCi with testes and urinary bladder as the critical organ for male and female, respectively.
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影响因子：
3.4
作者：
Carr, Gregory V.;Lucki, Irwin
通讯作者：
Lucki, Irwin
影响因子：
9.3
作者：
Milak, Matthew S.;Severance, Alin J.;Parsey, Ramin V.
通讯作者：
Parsey, Ramin V.
DOI：
10.1017/s1461145707008140
发表时间：
2008-06-01
影响因子：
4.8
作者：
Hirvonen, Jussi;Karlsson, Hasse;Hietala, Jarmo
通讯作者：
Hietala, Jarmo
影响因子：
10.6
作者：
Sullivan, Gregory M.;Ogden, R. Todd;Oquendo, Maria A.;Kumar, J. S. Dileep;Simpson, Norman;Huang, Yung-yu;Mann, J. John;Parsey, Ramin V.
通讯作者：
Parsey, Ramin V.
影响因子：
1.5
作者：
Parsey, Ramin V.;Sokol, Levi O.;Mann, J. John
通讯作者：
Mann, J. John