Skeletal Muscle and Bone - Emerging Targets of Fibroblast Growth Factor-21.
Skeletal Muscle and Bone - Emerging Targets of Fibroblast Growth Factor-21.
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DOI：
10.3389/fphys.2021.625287
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发表时间：
2021
影响因子：
4
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Sun H;Sherrier M;Li H
成纤维细胞生长因子21（FGF 21）是FGF家族的非典型成员，其作为葡萄糖和脂质代谢的强有力的内分泌和旁分泌调节剂起作用。除了肝脏和脂肪组织，最近的研究表明，FGF21也可以在骨骼肌中产生。骨骼肌作为人体中最丰富的组织，越来越被认为是代谢活动的主要场所和全身代谢稳态的重要调节剂。肌源性FGF 21的功能和作用机制最近由于发现在某些病理条件下骨骼肌中FGF 21的表达和分泌显著增加而受到关注。最近关于骨骼肌异位表达FGF21及其对肌肉骨骼系统的潜在影响的报道，揭开了FGF21故事的新篇章。在这篇综述中，我们总结了目前的知识基础，肌肉来源的FGF21和可能的功能，FGF21对肌肉骨骼系统的稳态，重点是骨骼肌和骨。
Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family, which functions as a powerful endocrine and paracrine regulator of glucose and lipid metabolism. In addition to liver and adipose tissue, recent studies have shown that FGF21 can also be produced in skeletal muscle. As the most abundant tissue in the human body, skeletal muscle has become increasingly recognized as a major site of metabolic activity and an important modulator of systemic metabolic homeostasis. The function and mechanism of action of muscle-derived FGF21 have recently gained attention due to the findings of considerably increased expression and secretion of FGF21 from skeletal muscle under certain pathological conditions. Recent reports regarding the ectopic expression of FGF21 from skeletal muscle and its potential effects on the musculoskeletal system unfolds a new chapter in the story of FGF21. In this review, we summarize the current knowledge base of muscle-derived FGF21 and the possible functions of FGF21 on homeostasis of the musculoskeletal system with a focus on skeletal muscle and bone.
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