Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Network Neuroimaging Study.
Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Network Neuroimaging Study.
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DOI：
10.1016/j.juro.2015.02.082
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发表时间：
2015-07
影响因子：
6.6
通讯作者：
Apkarian, A. Vania
中科院分区：
文献类型：
--
作者：
Farmer, Melissa A.;Huang, Lejian;Martucci, Katherine;Yang, Claire C.;Maravilla, Kenneth R.;Harris, Richard E.;Clauw, Daniel J.;Mackey, Sean;Ellingson, Benjamin M.;Mayer, Emeran A.;Schaeffer, Anthony J.;Apkarian, A. Vania
几种慢性疼痛状况可以通过通过成像观察到的状况特异性脑解剖和功能异常来区分，这些异常提示潜在的疾病过程。在这里，我们提出了第一个表征IC/BPS相关的白色物质（轴突）异常的基础上，多中心神经影像学从多学科的方法来研究慢性盆腔疼痛（MAPP）研究网络。IC/BPS女性（n=34）和健康对照组（n=32）进行了评估的疼痛，情绪和日常功能的问卷调查。使用扩散张量成像（DTI）评估白色物质的微观结构，以模拟沿着轴突的定向水流或分数各向异性（FA）。沿着轴突的定向水流。进一步检查与临床参数相关的区域的性别和综合征依赖性。患有IC/BPS的女性表现出许多与疼痛严重程度、泌尿系统症状和生活质量受损相关的白色异常。IC/BPS的特征是右侧丘脑前辐射、左侧大钳和右侧纵束的FA降低。在右侧上级和双侧下纵束中检测到FA增加。第一个特征的脑白色物质异常的女性IC/BPS显示，区域减少和增加的白色物质的完整性，跨多个轴突束，与症状严重程度IC/BPS。考虑到白色异常与IC/BPS的标志性症状密切相关，包括膀胱疼痛和泌尿系统症状，脑解剖学改变表明神经病理学对慢性泌尿系盆腔疼痛的贡献。
Several chronic pain conditions may be distinguished by condition-specific brain anatomical and functional abnormalities observed by imaging suggestive of underlying disease processes. Here we present the first characterization of IC/BPS-associated white matter (axonal) abnormalities based on multi-center neuroimaging from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Women with IC/BPS (n=34) and healthy controls (n=32) were assessed with questionnaires on pain, mood, and daily function. White matter microstructure was evaluated with diffusion tensor imaging (DTI) to model directional water flow along axons, or fractional anisotropy (FA). Regions that correlated with clinical parameters were further examined for sex and syndrome dependence. Women with IC/BPS exhibited numerous white matter abnormalities that correlated with severity of pain, urinary symptoms, and impaired quality of life. IC/BPS was characterized by decreased FA in aspects of the right anterior thalamic radiation, left forceps major, and right longitudinal fasciculus. Increased FA was detected in the right superior and bilateral inferior longitudinal fasciculi. The first characterization of brain white matter abnormalities in women with IC/BPS reveals that regional decreases and increases in white matter integrity, across multiple axonal tracts, are associated with symptom severity in IC/BPS. Given that white matter abnormalities closely correlate with hallmark symptoms of IC/BPS, including bladder pain and urinary symptoms, brain anatomical alterations suggest neuropathological contributions to chronic urological pelvic pain.
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影响因子：
7.4
作者：
Ellingson BM;Mayer E;Harris RJ;Ashe-McNally C;Naliboff BD;Labus JS;Tillisch K
通讯作者：
Tillisch K
影响因子：
4.8
作者：
Catani, Marco
通讯作者：
Catani, Marco
影响因子：
6.6
作者：
Nickel, J. Curtis;Tripp, Dean A.;Nordling, Jorgen
通讯作者：
Nordling, Jorgen
影响因子：
5
作者：
Teepker, Michael;Menzler, Katja;Knake, Susanne
通讯作者：
Knake, Susanne
DOI：
10.1016/j.juro.2011.10.040
发表时间：
2012-02
期刊：
The Journal of urology
影响因子：
--
作者：
Konkle KS;Berry SH;Elliott MN;Hilton L;Suttorp MJ;Clauw DJ;Clemens JQ
通讯作者：
Clemens JQ