Comparison of an interstitial cystitis/bladder pain syndrome clinical cohort with symptomatic community women from the RAND Interstitial Cystitis Epidemiology study.
Comparison of an interstitial cystitis/bladder pain syndrome clinical cohort with symptomatic community women from the RAND Interstitial Cystitis Epidemiology study.
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DOI：
10.1016/j.juro.2011.10.040
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Clemens JQ
中科院分区：
文献类型：
--
作者：
Konkle KS;Berry SH;Elliott MN;Hilton L;Suttorp MJ;Clauw DJ;Clemens JQ
兰德公司间质性膀胱炎流行病学调查估计，2.7% 至 6.5% 的美国女性有符合间质性膀胱炎/膀胱疼痛综合征诊断的泌尿系统症状。我们描述了基于症状社区的兰德间质性膀胱炎流行病学队列的人口统计和临床特征，并将其与基于临床的间质性膀胱炎/膀胱疼痛综合征队列进行比较。受试者包括 3,397 名符合兰德间质性膀胱炎流行病学高敏感性病例定义标准的社区女性，以及从美国各地的专家诊所招募的 277 名诊断为间质性膀胱炎/膀胱疼痛综合征的女性（临床队列）。问题集中在人口统计信息、症状严重程度、生活质量指标、伴随诊断和治疗。两组的平均症状持续时间约为 14 年。临床队列中的女性报告基线疼痛和最大疼痛更严重，尽管绝对差异很小。两组的平均间质性膀胱炎症状指数得分约为 11，但临床队列和 RAND 间质性膀胱炎流行病学队列的平均间质性膀胱炎问题指数得分分别为 9.9 和 13.2 (p <0.001)。兰德间质性膀胱炎流行病学受试者更有可能没有保险。兰德间质性膀胱炎流行病学社区队列在人口统计、症状和生活质量指标方面与间质性膀胱炎/膀胱疼痛综合征临床队列非常相似。与其他慢性疼痛疾病相比，临床队列通常报告的症状和功能状态比基于人群的样本更差，我们的数据表明，兰德间质性膀胱炎流行病学队列中许多症状严重程度和功能影响的衡量标准相似，有时甚至更差。这些研究结果表明，间质性膀胱炎/膀胱疼痛综合征非常严重，并且在美国可能没有得到充分的诊断和治疗。
The RAND Interstitial Cystitis Epidemiology survey estimated that 2.7% to 6.5% of United States women have urinary symptoms consistent with a diagnosis of interstitial cystitis/bladder pain syndrome. We describe the demographic and clinical characteristics of the symptomatic community based RAND Interstitial Cystitis Epidemiology cohort, and compare them with those of a clinically based interstitial cystitis/bladder pain syndrome cohort. Subjects included 3,397 community women who met the criteria for the RAND Interstitial Cystitis Epidemiology high sensitivity case definition, and 277 women with an interstitial cystitis/bladder pain syndrome diagnosis recruited from specialist practices across the United States (clinical cohort). Questions focused on demographic information, symptom severity, quality of life indicators, concomitant diagnoses and treatment. Average symptom duration for both groups was approximately 14 years. Women in the clinical cohort reported worse baseline pain and maximum pain, although the absolute differences were small. Mean Interstitial Cystitis Symptom Index scores were approximately 11 for both groups, but mean Interstitial Cystitis Problem Index scores were 9.9 and 13.2 for the clinical cohort and the RAND Interstitial Cystitis Epidemiology cohort, respectively (p <0.001). The RAND Interstitial Cystitis Epidemiology subjects were more likely to be uninsured. The RAND Interstitial Cystitis Epidemiology community cohort was remarkably similar to an interstitial cystitis/bladder pain syndrome clinical cohort with respect to demographics, symptoms and quality of life measures. In contrast to other chronic pain conditions for which clinical cohorts typically report worse symptoms and functional status than population based samples, our data suggest that many measures of symptom severity and functional impact are similar, and sometimes worse, in the RAND Interstitial Cystitis Epidemiology cohort. These findings suggest that interstitial cystitis/bladder pain syndrome is significantly burdensome, and likely to be underdiagnosed and undertreated in the United States.
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影响因子：
2.1
作者：
Lifford, Karen L.;Curhan, Gary C.
通讯作者：
Curhan, Gary C.
影响因子：
6.6
作者：
Leppilahti, M;Tammela, TLJ;Auvinen, A
通讯作者：
Auvinen, A
影响因子：
29.4
作者：
DROSSMAN, DA;MCKEE, DC;BURGER, AL
通讯作者：
BURGER, AL
DOI：
10.1016/j.juro.2011.03.132
发表时间：
2011-08
期刊：
The Journal of urology
影响因子：
--
作者：
Berry SH;Elliott MN;Suttorp M;Bogart LM;Stoto MA;Eggers P;Nyberg L;Clemens JQ
通讯作者：
Clemens JQ
影响因子：
4.7
作者：
Rode, S;Salkovskis, P;Hanna, M
通讯作者：
Hanna, M