COVID-19 in People Living with HIV: A Systematic Review and Meta-Analysis.
COVID-19 in People Living with HIV: A Systematic Review and Meta-Analysis.
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DOI：
10.3390/ijerph18073554
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发表时间：
2021-03-30
影响因子：
--
通讯作者：
Lye MS
中科院分区：
文献类型：
--
作者：
Lee KW;Yap SF;Ngeow YF;Lye MS
COVID-19是一个全球性的卫生紧急情况。人类免疫缺陷病毒（PLHIV）感染者担心他们是否有更高的感染风险并遭受更糟糕的COVID-19结果。关于这些问题的研究结果在很大程度上是不一致的。我们的目的是确定感染COVID-19的艾滋病毒感染者的流行病学特征、临床体征和症状、血液参数和临床结局。通过Medline、Cinahl和PubMed数据库识别相关研究。荟萃分析采用随机效应模型，置信区间为95%。82项研究被纳入系统综述，67项研究被纳入荟萃分析。根据7项队列研究的数据，COVID-19在艾滋病毒感染者中的合并发病率比例为0.9%（95%CI 0.6%，1.1%）。总体而言，28.4%的患者住院治疗，其中2.5%为严重危重病例，3.5%需要重症监护。总死亡率为5.3%。高血压是最常报告的合并症（24.0%）。发热（71.1%）是最常见的症状。胸部影像学显示了广泛的异常结果，包括常见的变化，如磨玻璃样阴影和实变以及一系列不太常见的异常。炎症标志物的实验室检测显示C反应蛋白、铁蛋白和白细胞介素-6经常升高，尽管程度不同。临床特征以及胸部影像学和实验室检查结果在高效抗逆转录病毒治疗（HAART）治疗和未治疗的患者中相似。未发现感染艾滋病毒者出现COVID-19不良结局的风险更高。因此，在COVID-19管理中，他们似乎可以像对待艾滋病毒阴性个体一样对待。然而，由于大流行形势正在迅速演变，可能需要更多的证据才能得出明确的建议。
COVID-19 is a global health emergency. People living with human immunodeficiency virus (PLHIV) have concerns about whether they have a higher risk of getting the infection and suffer worse COVID-19 outcomes. Findings from studies on these questions have largely been inconsistent. We aimed to determine the epidemiological characteristics, clinical signs and symptoms, blood parameters, and clinical outcomes among PLHIV who contracted COVID-19. Relevant studies were identified through Medline, Cinahl, and PubMed databases. A random-effects model was used in meta-analyses with a 95% confidence interval. Eighty-two studies were included in the systematic review and sixty-seven studies for the meta-analysis. The pooled incidence proportion of COVID-19 among PLHIV was 0.9% (95% CI 0.6%, 1.1%) based on the data from seven cohort studies. Overall, 28.4% were hospitalised, of whom, 2.5% was severe-critical cases and 3.5% needed intensive care. The overall mortality rate was 5.3%. Hypertension was the most commonly reported comorbidity (24.0%). Fever (71.1%) was the most common symptom. Chest imaging demonstrated a wide range of abnormal findings encompassing common changes such as ground glass opacities and consolidation as well as a spectrum of less common abnormalities. Laboratory testing of inflammation markers showed that C-reactive protein, ferritin, and interleukin-6 were frequently elevated, albeit to different extents. Clinical features as well as the results of chest imaging and laboratory testing were similar in highly active antiretroviral therapy (HAART)-treated and non-treated patients. PLHIV were not found to be at higher risk for adverse outcomes of COVID-19. Hence, in COVID-19 management, it appears that they can be treated the same way as HIV negative individuals. Nevertheless, as the pandemic situation is rapidly evolving, more evidence may be needed to arrive at definitive recommendations.
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影响因子：
11.8
作者：
Dandachi, Dima;Geiger, Grant;Chow, Jeremy
通讯作者：
Chow, Jeremy
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
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通讯作者：
COVE Study Group
影响因子：
6
作者：
Byrd, Katrina M.;Beckwith, Curt G.;Kantor, Rami
通讯作者：
Kantor, Rami
影响因子：
1.4
作者：
Chiappe Gonzalez AJ;Montenegro-Idrogo JJ;Vargas Vadillo AR;Slee Torres M;Vargas Matos I;Resurrección Delgado CP
通讯作者：
Resurrección Delgado CP
影响因子：
7.5
作者：
Calza, Leonardo;Bon, Isabella;Attard, Luciano
通讯作者：
Attard, Luciano