Liver stiffness measurement-based scoring system for significant inflammation related to chronic hepatitis B.
Liver stiffness measurement-based scoring system for significant inflammation related to chronic hepatitis B.
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DOI：
10.1371/journal.pone.0111641
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Pan JS
中科院分区：
文献类型：
--
作者：
Hong MZ;Zhang RM;Chen GL;Huang WQ;Min F;Chen T;Xu JC;Pan JS
肝活检是必不可少的，因为单独测量肝硬度不能提供肝内炎症的信息。然而，纤维化的存在与炎症高度相关。我们建立了一个非侵入性模型，通过使用肝硬度测量和血清标志物来确定慢性B型肝炎患者的显著炎症。训练集包括慢性B型肝炎患者（n = 327），验证集包括106例患者;进行肝活检，肝组织学评分，并调查血清标志物。 所有患者均接受肝脏硬度测量。构建了显著炎症的炎症活动性评分系统。在训练集中，基于纤维化的活动性评分的曲线下面积、灵敏度和特异性在HBeAg（+）患者中分别为0.964、91.9%和90.8%，在HBeAg（-）患者中分别为0.978、85.0%和94.0%。在验证集中，HBeAg（+）患者中基于纤维化的活动性评分的曲线下面积、灵敏度和特异性分别为0.971、90.5%和92.5%，HBeAg（-）患者中分别为0.977、95.2%和95.8%。在HBeAg（+）和HBeAg（-）患者中，基于肝硬度测量的活动评分与基于纤维化的活动评分在识别显著炎症（G ≥3）方面相当。通过这种新方法可以准确地预测严重的炎症。基于肝脏硬度测量的评分系统可以在没有计算机的帮助下使用，并为预测慢性乙型肝炎相关的显著炎症提供了一种非侵入性的替代方法。
Liver biopsy is indispensable because liver stiffness measurement alone cannot provide information on intrahepatic inflammation. However, the presence of fibrosis highly correlates with inflammation. We constructed a noninvasive model to determine significant inflammation in chronic hepatitis B patients by using liver stiffness measurement and serum markers. The training set included chronic hepatitis B patients (n = 327), and the validation set included 106 patients; liver biopsies were performed, liver histology was scored, and serum markers were investigated. All patients underwent liver stiffness measurement. An inflammation activity scoring system for significant inflammation was constructed. In the training set, the area under the curve, sensitivity, and specificity of the fibrosis-based activity score were 0.964, 91.9%, and 90.8% in the HBeAg(+) patients and 0.978, 85.0%, and 94.0% in the HBeAg(−) patients, respectively. In the validation set, the area under the curve, sensitivity, and specificity of the fibrosis-based activity score were 0.971, 90.5%, and 92.5% in the HBeAg(+) patients and 0.977, 95.2%, and 95.8% in the HBeAg(−) patients. The liver stiffness measurement-based activity score was comparable to that of the fibrosis-based activity score in both HBeAg(+) and HBeAg(−) patients for recognizing significant inflammation (G ≥3). Significant inflammation can be accurately predicted by this novel method. The liver stiffness measurement-based scoring system can be used without the aid of computers and provides a noninvasive alternative for the prediction of chronic hepatitis B-related significant inflammation.
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DOI：
10.1186/1476-5926-3-8
发表时间：
2004-09-23
期刊：
Comparative hepatology
影响因子：
--
作者：
Poynard T;Imbert-Bismut F;Munteanu M;Messous D;Myers RP;Thabut D;Ratziu V;Mercadier A;Benhamou Y;Hainque B
通讯作者：
Hainque B
影响因子：
168.9
作者：
Imbert-Bismut, F;Ratziu, V;Poynard, T
通讯作者：
Poynard, T
影响因子：
2.5
作者：
Coco, B.;Oliveri, F.;Brunetto, M. R.
通讯作者：
Brunetto, M. R.
影响因子：
24.5
作者：
Foucher, J;Chanteloup, E;de Lédinghen, V
通讯作者：
de Lédinghen, V
影响因子：
2.8
作者：
Cho, Hyo Jung;Kim, Soon Sun;Cheong, Jae Youn
通讯作者：
Cheong, Jae Youn