Neuroprotections and mechanisms of inhalational anesthetics against brain ischemia.
Neuroprotections and mechanisms of inhalational anesthetics against brain ischemia.
复制标题
吸入麻醉药对抗脑缺血的神经保护和机制。
DOI：
10.2741/e189
复制
发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
新一代吸入麻醉药因其安全性、可靠性和有效性而被广泛应用于临床和实验环境中的全身麻醉。最近发现了一些麻醉剂的神经保护作用，包括挥发性气体异氟烷、七氟烷和地氟烷，以及惰性气体氙气。体内和体外研究表明，这些气体能够保护大脑免受缺血损伤，这表明梗塞体积和神经元凋亡的减少。在这篇综述中，我们[请参见表1]将简要介绍这些气体的性质，并详细讨论它们对脑缺血的影响、有效的治疗方案和神经保护机制。并对吸入性麻醉药的未来研究和应用进行了展望。
The new generation of inhalational anesthetics has been widely used for general anesthesia in both clinical and experimental settings because of their safety, reliability and potency. A neuroprotective role has recently been revealed for some of these anesthetics, including the volatile gases isoflurane, sevoflurane, and desflurane, as well as the inert gas xenon. In vivo and in vitro studies have demonstrated that these gases were able to protect brain against ischemic injury, indicated by the decreases in infarct volumes and neuronal apoptosis. In this review, we [Please see table 1] will briefly introduce the properties of these gases, and discuss in detail their effects on brain ischemia, effective treatment regimens, and neuroprotective mechanisms. Perspectives are also discussed on future study and use of inhalational anesthetics.
登录
查看更多内容
影响因子：
8.3
作者：
Thrift, AG;Dewey, HM;Donnan, GA
通讯作者：
Donnan, GA
影响因子：
6.3
作者：
Ma, DQ;Hossain, M;Maze, M
通讯作者：
Maze, M
DOI：
10.1007/s12630-009-9166-y
发表时间：
2009-09
期刊：
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
影响因子：
--
作者：
C. Werner
通讯作者：
C. Werner
影响因子：
8.8
作者：
J. Messick;B. Casement;F. Sharbrough;L. N. Milde;J. Michenfelder;T. Sundt
通讯作者：
J. Messick;B. Casement;F. Sharbrough;L. N. Milde;J. Michenfelder;T. Sundt