Serum antioxidants and age-related macular degeneration among older Japanese.
Serum antioxidants and age-related macular degeneration among older Japanese.
复制标题
日本老年人的血清抗氧化剂和年龄相关性黄斑变性。
DOI：
--
复制
发表时间：
2009
影响因子：
1.3
通讯作者：
T. Takebayashi
中科院分区：
文献类型：
--
作者：
T. Michikawa;S. Ishida;Y. Nishiwaki;Y. Kikuchi;T. Tsuboi;K. Hosoda;A. Ishigami;S. Iwasawa;M. Nakano;T. Takebayashi
从人类营养的角度来看，通过饮食控制预防老年性黄斑变性（AMD）是可行和可取的。我们调查了社区居住的日本老年人食用典型的日本饮食中血清抗氧化剂与AMD之间的关系。本研究纳入了722名年龄在65岁及以上的受试者（男性297人，女性425人），他们有可分级的眼底照片。受试者分为早期、晚期黄斑变性组和非黄斑病变组。采用高效液相色谱法测定血清抗氧化剂（α -、γ -生育酚、视黄醇、β -隐黄质、α -、β -胡萝卜素、番茄红素、叶黄素和玉米黄质）。为了明确抗氧化剂的综合作用，我们定义了胡萝卜素家族（α -、β -胡萝卜素和番茄红素）和类胡萝卜素家族（β -隐黄质、α -、β -胡萝卜素、番茄红素、叶黄素和玉米黄质）。测定各组血清抗氧化剂的含量，并采用单因素或多因素分析比较早、晚期AMD的患病率。早期AMD的总体患病率为4.4%(95%可信区间：3.1-6.2)，晚期AMD的患病率为1.1%（0.5-2.2）。只有α -生育酚和β -隐黄质作为单一抗氧化剂与晚期AMD有关。另一方面，胡萝卜素和类胡萝卜素家族作为抗氧化剂的组合与晚期AMD有保护作用。血清抗氧化剂与早期AMD无相关性。我们的研究结果支持了一种假设，即从传统日本饮食中获得的血清抗氧化剂对晚期AMD有保护作用，但对早期AMD没有保护作用。
From the perspective of human nutrition, the prevention of age-related macular degeneration (AMD) through diet control is feasible and desirable. We investigated the relationship between serum antioxidants and AMD in the community-dwelling older Japanese eating a typical Japanese diet. In this study, 722 subjects aged 65 years or older (297 males and 425 females) who had gradable fundus photographs were included. The subjects were divided into three groups of early or late AMD or non-maculopathy. Serum antioxidants (alpha-, gamma-tocopherols, retinol, beta-cryptoxanthin, alpha-, beta-carotenes, lycopene, and lutein and zeaxanthin) were measured with high-performance liquid chromatography. To clarify the combined effect as the group of the antioxidants, we defined the carotene family (alpha-, beta-carotenes and lycopene) and carotenoid family (beta-cryptoxanthin, alpha-, beta-carotenes, lycopene, lutein and zeaxanthin). Tertiles of each serum antioxidant were obtained and the prevalence of early or late AMD was compared with univariate or multivariate analysis. The overall prevalence of early AMD was 4.4% (95% confidence interval: 3.1-6.2) and late AMD was 1.1% (0.5-2.2). Only alpha-tocopherol and beta-cryptoxanthin were related to late AMD as single antioxidants. On the other hand, the carotene and carotenoid families as a combination of antioxidants were protectively associated with late AMD. No relationship was found between serum antioxidants and early AMD. Our findings support the hypothesis that a combination of serum antioxidants obtained from the traditional Japanese diet is protective for late AMD, but not for early AMD.
影响因子：
158.5
作者：
SOMMER, A;TIELSCH, JM;EZRINE, S
通讯作者：
EZRINE, S
影响因子：
--
作者：
Moeller, Suzen M.;Parekh, Niyati;Mares, Julie A.
通讯作者：
Mares, Julie A.
影响因子：
--
作者：
Cho, EY;Seddon, JM;Hankinson, SE
通讯作者：
Hankinson, SE