Systemic nicotine administration suppresses food intake via reduced meal sizes in both male and female rats.
Systemic nicotine administration suppresses food intake via reduced meal sizes in both male and female rats.
复制标题
全身尼古丁给药通过减少雄性和雌性大鼠的膳食量来抑制食物摄入。
DOI：
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复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Z. Zadák
中科院分区：
文献类型：
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作者：
V. Bláha;Z. Yang;M. Meguid;J. Chai;Z. Zadák
烟草制品通过主要药理尼古丁产生的食欲抑制作用是女性和男性使用烟草制品的主要原因。食物摄入量（FI）可以通过改变膳食量（MZ）或膳食数量（MN）来改变，这两者以相互的方式相互调节。本研究调查了全身尼古丁给药对大鼠喂养模式的影响。由于尼古丁影响的性别差异，对雄性和雌性大鼠都进行了研究。 Alzet 微型渗透泵（2001 型）和自动大鼠食量计用于评估雄性和雌性 Fischer 344 大鼠在全身尼古丁输注（6 mg/kg b.w. s.c.）7 天期间的喂养模式。主要发现是：1）全身性尼古丁输注减少了两性的食物摄入量； 2）食物摄入量减少是由于膳食量显着减少，而男性或女性的膳食数量没有显着改变； 3)雌性大鼠阴道涂片、食物摄入量、进餐次数和进餐量的周期模式不受尼古丁给药的影响。我们的结论是，尼古丁的摄食抑制作用是由于减少进餐量和饱腹感而产生的，与性激素无关。
The appetite suppressing effect of tobacco products, via the main pharmacological agent nicotine, is a major reason for its usage both by woman and man. Food intake (FI) could be changed by altering either meal size (MZ) or meal number (MN), which are regulated dependently in a reciprocal manner. The present study investigated the effect of systemic nicotine administration on the rat feeding pattern. Because of gender differences in the effects of nicotine, both male and female rats were studied. Alzet mini-osmotic pumps (Model 2001) and the automated rat eatometer were used to evaluate the feeding pattern of male and female Fischer 344 rats during seven days of systemic nicotine infusion (6 mg/kg b.w. s.c.). The main findings are: 1) systemic nicotine infusion decreased food intake in both sexes; 2) the decreased food intake was due to significantly reduced meal sizes while meal numbers were not altered significantly in either males or females; 3) the cyclical pattern of vaginal smears, food intake, meal number and meal size of female rats was not affected by nicotine administration. We conclude that the feeding suppressive effect of nicotine, which is due to reduced meal sizes and thus satiation, is not sex-hormones related.
DOI：
10.1037//0278-6133.14.2.116
发表时间：
1995
期刊：
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
影响因子：
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作者：
Audrain,JE;Klesges,RC;Klesges,LM
通讯作者：
Klesges,LM
烟碱胆碱能受体激活后，大鼠纹状体切片释放多巴胺和 5-羟色胺。
DOI：
10.1016/0306-3623(83)90037-x
发表时间：
1983
期刊：
General pharmacology
影响因子：
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作者：
Westfall,TC;Grant,H;Perry,H
通讯作者：
Perry,H