Role of bile acids in carcinogenesis of pancreatic cancer: An old topic with new perspective.
Role of bile acids in carcinogenesis of pancreatic cancer: An old topic with new perspective.
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胆汁酸在胰腺癌发生中的作用：老话题新视角
DOI：
10.3748/wjg.v22.i33.7463
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发表时间：
2016-09-07
影响因子：
4.3
通讯作者：
Chen YC
中科院分区：
文献类型：
--
作者：
Feng HY;Chen YC
胆汁酸在结直肠癌中的作用已被充分证明，但它们在胰腺癌中的作用仍不清楚。在这篇综述中，我们研究了胰腺癌的危险因素。我们发现胆汁酸与这些因素中的大多数相关。饮酒、吸烟、高脂饮食等都导致胆汁酸分泌过多，胆汁酸代谢功能障碍是胆结石的致病因素。胆汁酸分泌的增加，除了一个长的共同通道，可能会导致胆汁酸回流到胰腺导管和上皮细胞或腺泡细胞，胰腺癌是从其中衍生的。最后的病理生理过程是胰腺炎，它促进腺泡细胞去分化成祖导管样细胞。有趣的是，胆汁酸在代谢中充当调节分子，影响脂肪组织分布、胰岛素敏感性和甘油三酯代谢。因此，胆汁酸与胰腺癌的三个危险因素有关：肥胖、糖尿病和高胆固醇血症。本文第二部分综述了胆汁酸在胃肠道肿瘤中的促癌作用。然而，胆汁酸在胰腺癌发生中的作用还有待进一步的肿瘤学和生理学实验证实。
The role of bile acids in colorectal cancer has been well documented, but their role in pancreatic cancer remains unclear. In this review, we examined the risk factors of pancreatic cancer. We found that bile acids are associated with most of these factors. Alcohol intake, smoking, and a high-fat diet all lead to high secretion of bile acids, and bile acid metabolic dysfunction is a causal factor of gallstones. An increase in secretion of bile acids, in addition to a long common channel, may result in bile acid reflux into the pancreatic duct and to the epithelial cells or acinar cells, from which pancreatic adenocarcinoma is derived. The final pathophysiological process is pancreatitis, which promotes dedifferentiation of acinar cells into progenitor duct-like cells. Interestingly, bile acids act as regulatory molecules in metabolism, affecting adipose tissue distribution, insulin sensitivity and triglyceride metabolism. As a result, bile acids are associated with three risk factors of pancreatic cancer: obesity, diabetes and hypertriglyceridemia. In the second part of this review, we summarize several studies showing that bile acids act as cancer promoters in gastrointestinal cancer. However, more question are raised than have been solved, and further oncological and physiological experiments are needed to confirm the role of bile acids in pancreatic cancer carcinogenesis.
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影响因子：
3.6
作者：
Cătoi AF;Pârvu A;Mureşan A;Busetto L
通讯作者：
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影响因子：
29.4
作者：
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影响因子：
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影响因子：
5.1
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影响因子：
29.4
作者：
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通讯作者：
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