The fetal programming of telomere biology hypothesis: an update.
The fetal programming of telomere biology hypothesis: an update.
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端粒生物学假设的胎儿编程：更新。
DOI：
10.1098/rstb.2017.0151
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发表时间：
2018-03-05
期刊：
影响因子：
--
通讯作者：
Wadhwa PD
中科院分区：
文献类型：
--
作者：
Entringer S;de Punder K;Buss C;Wadhwa PD
对胎儿健康和疾病风险编程机制的研究主要集中在特定于感兴趣的细胞类型、器官或表型的过程上。然而，观察到发育条件伴随着影响一组不同的表型，其中大多数涉及年龄相关的疾病，提出了这样的发育条件可能会通过一个共同的潜在机制，涉及细胞/分子衰老相关的过程，另外发挥作用的可能性。在这种情况下，我们认为端粒生物学代表了人类特别感兴趣的过程，因为，首先，该系统代表了常见年龄相关疾病的最显着的先行细胞表型;其次，其初始（新生儿）设置似乎对其长期影响特别重要;第三，其初始设置似乎是塑料和发育调节下。我们提出，次优的子宫内条件对端粒长度和端粒酶表达/活性能力的初始设置的影响可能是介导的编程动作的压力相关的母亲-胎盘-胎儿的氧化，免疫，内分泌和代谢途径的方式，最终可能加速细胞功能障碍，衰老和疾病易感性的寿命。这份展望文件概述了这一假设的每一个基本要素，重点是最近的事态发展，调查结果和未来的方向。这篇文章是“理解端粒动力学的多样性”主题的一部分。
Research on mechanisms underlying fetal programming of health and disease risk has focused primarily on processes that are specific to cell types, organs or phenotypes of interest. However, the observation that developmental conditions concomitantly influence a diverse set of phenotypes, the majority of which are implicated in age-related disorders, raises the possibility that such developmental conditions may additionally exert effects via a common underlying mechanism that involves cellular/molecular ageing–related processes. In this context, we submit that telomere biology represents a process of particular interest in humans because, firstly, this system represents among the most salient antecedent cellular phenotypes for common age-related disorders; secondly, its initial (newborn) setting appears to be particularly important for its long-term effects; and thirdly, its initial setting appears to be plastic and under developmental regulation. We propose that the effects of suboptimal intrauterine conditions on the initial setting of telomere length and telomerase expression/activity capacity may be mediated by the programming actions of stress-related maternal–placental–fetal oxidative, immune, endocrine and metabolic pathways in a manner that may ultimately accelerate cellular dysfunction, ageing and disease susceptibility over the lifespan. This perspectives paper provides an overview of each of the elements underlying this hypothesis, with an emphasis on recent developments, findings and future directions. This article is part of the theme issue ‘Understanding diversity in telomere dynamics’.
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影响因子：
3.6
作者：
Achi, MV;Ravindranath, N;Dym, M
通讯作者：
Dym, M
DOI：
10.1096/fj.201500057
发表时间：
2016-05
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Allison BJ;Kaandorp JJ;Kane AD;Camm EJ;Lusby C;Cross CM;Nevin-Dolan R;Thakor AS;Derks JB;Tarry-Adkins JL;Ozanne SE;Giussani DA
通讯作者：
Giussani DA
影响因子：
7.8
作者：
Benetos A;Kark JD;Susser E;Kimura M;Sinnreich R;Chen W;Steenstrup T;Christensen K;Herbig U;von Bornemann Hjelmborg J;Srinivasan SR;Berenson GS;Labat C;Aviv A
通讯作者：
Aviv A
影响因子：
7.8
作者：
Bakaysa, Stephanie L.;Mucci, Lorelei A.;Pedersen, Nancy L.
通讯作者：
Pedersen, Nancy L.
DOI：
10.1016/j.bbrc.2004.02.080
发表时间：
2004-04-02
影响因子：
3.1
作者：
Akiyama, M;Yamada, O;Anderson, KC
通讯作者：
Anderson, KC