T regulatory cells and transplantation tolerance.

T regulatory cells and transplantation tolerance.
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DOI:
10.1016/j.trre.2010.04.002
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发表时间:
2010-07
期刊:
Transplantation reviews (Orlando, Fla.)
影响因子:
--
通讯作者:
Zheng XX
Zheng XX
中科院分区:
其他
文献类型:
--
作者:
Gorantla VS;Schneeberger S;Brandacher G;Sucher R;Zhang D;Lee WP;Zheng XX

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尽管开发了成功的免疫抑制方案并极大地提高了移植物的短期存活率,但慢性移植物丢失的问题仍然是临床移植的祸根。移植耐受的诱导和维持是移植的“圣杯”。最近调节性T细胞(T Regs)的鉴定和鉴定为移植耐受诱导、免疫治疗和免疫调节提供了令人兴奋的机会。本文就调节性T细胞及其在移植耐受中的作用进行综述。
Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the “Holy grail” of transplantation. The recent identification and characterization of regulatory T cells (T regs) has opened up exciting opportunities for tolerance induction, immunotherapy and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.
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