Thyroid status and thermogenesis in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Thyroid status and thermogenesis in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
复制标题
用 2,3,7,8-四氯二苯并-对-二恶英治疗的大鼠的甲状腺状态和生热作用。
DOI：
10.1016/0041-008x(86)90415-1
复制
发表时间：
1986
影响因子：
3.8
通讯作者：
Peterson,RE
中科院分区：
文献类型：
--
作者：
Potter,CL;Moore,RW;Inhorn,SL;Hagen,TC;Peterson,RE
2，3，7，8-四氯二苯并对二恶英（TCDD）毒性的几个关键方面类似于甲状腺功能减退症的影响，而在其他方面的毒性反应是甲状腺功能亢进症的特征。然而，甲状腺功能障碍是否在TCDD毒性中起作用仍不清楚。因此，我们确定了TCDD治疗对l-甲状腺素（T4）、3，5，3 '-三碘-l-甲状腺原氨酸（T3）和促甲状腺激素（TSH）血浆浓度的剂量相关影响，并将这些变化与TCDD毒性体征进行比较。我们还确定了甲状腺功能状态（和产热）的指数是否改变，在响应TCDD治疗。年轻的成年雄性Sprague-Dawley大鼠单次口服剂量的TCDD（6.25-100 μg/kg），并在1周后进行评估。毒性，通过减少摄食量和体重来衡量，范围从轻微到严重。在所有试验剂量下，T4的血浆浓度均大幅降低，而T3则以剂量相关方式升高（高达35%）。TSH升高，但与剂量成反比。甲状腺组织学是不显着的，和TCDD治疗的能力，大鼠提高血清T4，T3，TSH浓度在急性冷应激的影响不大。TCDD治疗导致基础代谢率轻微（8%）下降，但在配对喂养的对照动物中观察到相当的下降。产热，作为衡量O2消耗和结肠温度暴露于各种环境温度的大鼠，只有轻微的影响。总之，虽然甲状腺激素浓度显着改变，大鼠给予剂量的TCDD足以引起明显的毒性似乎基本上是甲状腺功能正常。这些结果不支持其他研究人员的提议，即甲状腺状态改变是TCDD毒性的主要贡献者和/或对TCDD暴露的关键反应。
Several key aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity resemble the effects of hypothyroidism, while in other ways the toxic responses are characteristic of hyperthyroidism. Whether thyroid dysfunction plays a role in TCDD toxicity remained unknown, however. We therefore determined the dose-related effects of TCDD treatment on plasma concentrations of l-thyroxine (T4), 3,5,3′-triiodo-l-thyronine (T3), and thyroid-stimulating hormone (TSH), and compared these changes with signs of TCDD toxicity. We also determined whether indices of functional thyroid status (and thermogenesis) were altered in response to TCDD treatment. Young adult male Sprague-Dawley rats were given single oral doses of TCDD (6.25–100 μg/kg) and evaluated 1 week later. Toxicity, measured by decreases in feed intake and body weight, ranged from minimal to severe. Plasma concentrations of T4were greatly reduced at all doses tested, while T3was increased in a dose-related fashion (up to 35%). TSH was elevated but was inversely proportional to dose. Thyroid histology was unremarkable, and TCDD treatment had little effect on the ability of rats to raise serum T4, T3, and TSH concentrations in response to acute cold stress. TCDD treatment caused a slight (8%) decrease in basal metabolic rate, yet comparable decreases were seen in pair-fed control animals. Thermogenesis, as measured by O2consumption and colonic temperatures in rats exposed to various ambient temperatures, was only marginally affected. In summary, although thyroid hormone concentrations were markedly altered, rats given doses of TCDD sufficient to cause overt toxicity appeared to be essentially euthyroid. These results do not support proposals by other researchers that altered thyroid status is a major contributor to TCDD toxicity and/or a key response to TCDD exposure.
登录
查看更多内容
通过结合使用血清蛋白结合碘和树脂摄取 131-I-三碘甲腺原氨酸来评估甲状腺功能。
影响因子：
5.8
作者：
F. Clark;D. B. Horn
通讯作者：
D. B. Horn
δ9-四氢大麻酚对大鼠血清促甲状腺素水平的影响
影响因子：
3.6
作者：
C. Hillard;N. Farber;T. C. Hagen;A. Bloom
通讯作者：
A. Bloom
改变大鼠肝脏混合功能氧化酶（MFO）活性对2,3,7,8-四氯二苯并-对二恶英（TCDD）毒性的影响。
影响因子：
3.8
作者：
Patrick W. Beatty;William K. Vaughn;Robert A. Neal
通讯作者：
Robert A. Neal
甲状腺激素对不依赖胆盐的胆汁流量和胆小管中富集的肝质膜中Na，K-ATP酶活性的影响。
影响因子：
15.9
作者：
James;L.;Boyer
通讯作者：
Boyer
食物剥夺对大鼠甲状腺素外周代谢的影响。
影响因子：
4.8
作者：
D. Ingbar;V. Galton
通讯作者：
V. Galton