Electroconvulsive Shock Does Not Impair the Reconsolidation of Cued and Contextual Pavlovian Threat Memory.
Electroconvulsive Shock Does Not Impair the Reconsolidation of Cued and Contextual Pavlovian Threat Memory.
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DOI：
10.3390/ijms21197072
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发表时间：
2020-09-25
影响因子：
5.6
通讯作者：
Ploski JE
中科院分区：
文献类型：
--
作者：
Elahi H;Hong V;Ploski JE
现有的记忆，当在某些情况下被检索时，可以通过蛋白质合成依赖的再巩固过程进行修改。这一过程的破坏可能导致记忆痕迹的减弱，这种方法正在被研究作为一种潜在的治疗方法，以病理记忆为特征，如创伤后应激障碍。这种方法的成功依赖于稳健地减弱再整合的能力；然而，现有文献对用于实现这种阻断的各种药物的可靠性提出了质疑。确定一种药物或干预措施，可以可靠地破坏再巩固，而不需要颅内通道政府将是非常有用的。一些研究表明，记忆提取后的电休克（ECS）会破坏记忆的再巩固；然而，缺乏文献描述其对巴甫洛夫恐惧记忆的影响。考虑到这一点，我们选择将ECS作为一种廉价且简便的方法来检查大鼠的再巩固。本研究表明，在记忆恢复后（立即、30分钟后或1小时后）使用电痉挛诱发癫痫，不会损害线索或情境巴甫洛夫恐惧记忆的再巩固。相反，在消退训练后立即给予ECS可能会适度损害恐惧消退记忆的巩固。
Existing memories, when retrieved under certain circumstances, can undergo modification through the protein synthesis-dependent process of reconsolidation. Disruption of this process can lead to the weakening of a memory trace, an approach which is being examined as a potential treatment for disorders characterized by pathological memories, such as Post-Traumatic Stress Disorder. The success of this approach relies upon the ability to robustly attenuate reconsolidation; however, the available literature brings into question the reliability of the various drugs used to achieve such a blockade. The identification of a drug or intervention that can reliably disrupt reconsolidation without requiring intracranial access for administration would be extremely useful. Electroconvulsive shock (ECS) delivered after memory retrieval has been demonstrated in some studies to disrupt memory reconsolidation; however, there exists a paucity of literature characterizing its effects on Pavlovian fear memory. Considering this, we chose to examine ECS as an inexpensive and facile means to impair reconsolidation in rats. Here we show that electroconvulsive seizure induction, when administered after memory retrieval, (immediately, after 30 min, or after 1 h), does not impair the reconsolidation of cued or contextual Pavlovian fear memories. On the contrary, ECS administration immediately after extinction training may modestly impair the consolidation of fear extinction memory.
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影响因子：
1.8
作者：
Lu, Tsun-Jung;Lu, Ru-Band;Yu, Lung
通讯作者：
Yu, Lung
影响因子：
5.3
作者：
Lagasse, Fabrice;Devaud, Jean-Marc;Mery, Frederic
通讯作者：
Mery, Frederic
影响因子：
15.9
作者：
Lee, Jonathan L C
通讯作者：
Lee, Jonathan L C
DOI：
10.1037/h0033524
发表时间：
1972-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
LEWIS, DJ;MAHAN, JJ;BREGMAN, NJ
通讯作者：
BREGMAN, NJ
影响因子：
2.3
作者：
GREENOUGH, WT;SCHWITZGEBEL, RL
通讯作者：
SCHWITZGEBEL, RL