Metabolic profile in early pregnancy is associated with offspring adiposity at 4 years of age: the Rhea pregnancy cohort Crete, Greece.
Metabolic profile in early pregnancy is associated with offspring adiposity at 4 years of age: the Rhea pregnancy cohort Crete, Greece.
复制标题
怀孕早期的代谢特征与4岁的后代肥胖有关：希腊的Rhea妊娠同龄人。
DOI：
10.1371/journal.pone.0126327
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Chatzi L
中科院分区：
文献类型：
--
作者：
Daraki V;Georgiou V;Papavasiliou S;Chalkiadaki G;Karahaliou M;Koinaki S;Sarri K;Vassilaki M;Kogevinas M;Chatzi L
孕妇孕前肥胖可能会增加儿童肥胖的风险，但尚不清楚妊娠早期的其他代谢因素，如血脂和高血压是否与后代的心脏代谢特征有关。我们的目的是调查妊娠早期空腹脂质、葡萄糖和胰岛素水平以及母亲孕前体重状况是否与后代学龄前肥胖测量、脂质水平和血压相关。该研究包括618对来自希腊克里特岛的怀孕队列“Rhea”研究的母子。在第一次产前访问时招募孕妇（平均：12周，SD: 0.7）。348名妇女提供了空腹血清样本用于葡萄糖和脂质测量。结果测量是体重指数、腹围、皮褶厚度总和和4岁时的血压测量。525名儿童的亚样本提供了非空腹血液样本用于脂质测量。孕前超重/肥胖与后代超重/肥胖（RR: 1.83, 95%CI: 1.19, 2.81）、中心性肥胖（RR: 1.97, 95%CI: 1.11, 3.49）和4岁时脂肪量增加5.10mm （95%CI: 2.49, 7.71）的风险较高相关。这些关联在女孩身上更为明显。妊娠早期空腹血清胆固醇水平增加40mg/dl与4岁时皮褶厚度增加3.30mm （95%CI: 1.41, 5.20）相关，在调整孕前BMI和其他几个混杂因素后。妊娠早期舒张压升高10mmHg与后代超重/肥胖的风险增加相关（RR: 1.22, 95%CI: 1.03, 1.45）， 4岁时皮褶厚度增加1.71mm （95% CI: 0.57, 2.86）。妊娠早期代谢失调可能会增加学龄前肥胖的风险。
Maternal pre-pregnancy obesity may increase the risk of childhood obesity but it is unknown whether other metabolic factors in early pregnancy such as lipid profile and hypertension are associated with offspring cardiometabolic traits. Our objective was to investigate whether fasting lipid, glucose, and insulin levels during early pregnancy and maternal pre-pregnancy weight status, are associated with offspring adiposity measures, lipid levels and blood pressure at preschool age. The study included 618 mother-child pairs of the pregnancy cohort “Rhea” study in Crete, Greece. Pregnant women were recruited at the first prenatal visit (mean: 12weeks, SD: 0.7). A subset of 348 women provided fasting serum samples for glucose and lipid measurements. Outcomes measures were body mass index, abdominal circumference, sum of skinfold thickness, and blood pressure measurements at 4 years of age. A subsample of 525 children provided non-fasting blood samples for lipid measurements. Pre-pregnancy overweight/obesity was associated with greater risk of offspring overweight/obesity (RR: 1.83, 95%CI: 1.19, 2.81), central adiposity (RR: 1.97, 95%CI: 1.11, 3.49), and greater fat mass by 5.10mm (95%CI: 2.49, 7.71) at 4 years of age. These associations were more pronounced in girls. An increase of 40mg/dl in fasting serum cholesterol levels in early pregnancy was associated with greater skinfold thickness by 3.30mm (95%CI: 1.41, 5.20) at 4 years of age after adjusting for pre-pregnancy BMI and several other confounders. An increase of 10mmHg in diastolic blood pressure in early pregnancy was associated with increased risk of offspring overweight/obesity (RR: 1.22, 95%CI: 1.03, 1.45), and greater skinfold thickness by 1.71mm (95% CI: 0.57, 2.86) at 4 years of age. Metabolic dysregulation in early pregnancy may increase the risk of obesity at preschool age.
登录
查看更多内容
DOI：
10.1056/nejmoa1309753
发表时间：
2014-01-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cunningham SA;Kramer MR;Narayan KM
通讯作者：
Narayan KM
影响因子：
3.7
作者：
Gabory A;Ferry L;Fajardy I;Jouneau L;Gothié JD;Vigé A;Fleur C;Mayeur S;Gallou-Kabani C;Gross MS;Attig L;Vambergue A;Lesage J;Reusens B;Vieau D;Remacle C;Jais JP;Junien C
通讯作者：
Junien C
DOI：
10.1073/pnas.1000440107
发表时间：
2010-03-23
影响因子：
11.1
作者：
Mao, Jiude;Zhang, Xia;Rosenfeld, Cheryl S.
通讯作者：
Rosenfeld, Cheryl S.
影响因子：
8.3
作者：
Gaillard, Romy;Steegers, Eric A. P.;Jaddoe, Vincent W. V.
通讯作者：
Jaddoe, Vincent W. V.
影响因子：
3.7
作者：
Bekkers MB;Brunekreef B;Smit HA;Kerkhof M;Koppelman GH;Oldenwening M;Wijga AH
通讯作者：
Wijga AH