Automatic semantic priming abnormalities in schizophrenia.
Automatic semantic priming abnormalities in schizophrenia.
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DOI：
10.1016/j.ijpsycho.2009.12.003
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发表时间：
2010-02
影响因子：
3
通讯作者：
Ford, Judith M.
中科院分区：
文献类型：
--
作者：
Mathalon, Daniel H.;Roach, Brian J.;Ford, Judith M.
语义网络的异常激活是精神分裂症的特征，可以使用N400事件相关电位（ERP）进行研究。N400是由没有被前面的上下文启动的词引起的，并且提供了对语义启动背后的神经机制的直接测量。语义启动是指通过预先暴露于语义语境中而获得的易化语义加工过程。我们预测：（1）精神分裂症患者具有过度包容的语义网络，反映在N400对相对未启动的单词的负面性低于预期;（2）精神分裂症患者在语义上下文的使用方面存在缺陷，对启动的单词做出反应，就好像它们是未启动的一样，反映在N400对启动的单词的负面性高于预期。N400是从DSM-IV精神分裂症患者（n=26）和年龄匹配的健康对照受试者（n=29）中获得的，他们执行图片-文字验证（匹配与不匹配）任务。单词目标在图片启动后325 ms呈现，这些图片要么匹配（CAMEL→“camel”），要么不匹配（In Category：CAMEL→“cow”; Out Category：CAMEL→“candle”）。N400数据表明，患者和对照组之间的差异启动和未启动的话是敏感的，但患者的敏感性低于对照组。同样，N400数据表明，两组人对未启动词类别之间的细微差异（在类别与在类别图片-词不匹配）敏感，但患者不太敏感，特别是那些有明显阴性症状的患者。
Abnormal activation of semantic networks characterizes schizophrenia and can be studied using the N400 event-related potential (ERP). N400 is elicited by words that are not primed by the preceding context and provides a direct measure of the neural mechanisms underlying semantic priming. Semantic priming refers to facilitated semantic processing gained through pre-exposure to semantic context, which can happen automatically if the interval between the prime and target is very short. We predicted that (1) schizophrenia patients have overly inclusive semantic networks, reflected in a less negative than expected N400 to relatively unprimed words, and (2) schizophrenia patients are deficient in their use of semantic context, responding to primed words as if they were unprimed, reflected in a more negative than expected N400 to primed words. N400s were acquired from patients with DSM-IV schizophrenia (n=26) and age-matched healthy comparison subjects (n=29) performing a picture-word verification (match vs. non-match) task. Word targets were presented 325ms after a picture prime, which either matched (CAMEL→”camel”), or did not match (In Category: CAMEL→”cow; Out Category: CAMEL→”candle”) the prime. N400 data suggest that both patients and controls are sensitive to the difference between primed and unprimed words, but patients are less sensitive than controls. Similarly, N400 data suggest that both groups were sensitive to the subtler difference between classes of unprimed words (In Category versus Out Category picture-word non-matches), but patients are less sensitive, especially those with prominent negative symptoms.
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DOI：
10.1016/0013-4694(96)95049-x
发表时间：
1996-09-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Ford, JM;Woodward, SH;Roth, WT
通讯作者：
Roth, WT
影响因子：
17.7
作者：
Kiang, Michael;Kutas, Marta;Braff, David L.
通讯作者：
Braff, David L.
影响因子：
2.5
作者：
HAMBERGER, MJ;FRIEDMAN, D;ROSEN, J
通讯作者：
ROSEN, J
影响因子：
3.2
作者：
Ganis, G;Kutas, M;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
17.7
作者：
Aloia, MS;Gourovitch, ML;Goldberg, TE
通讯作者：
Goldberg, TE